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© Marie-Christine Prévost, Anne Derbise
Bactéries Yersinia pestis en microscopie electronique à balayage.
Publication : Microbiology spectrum

Listeria monocytogenes: cell biology of invasion and intracellular growth

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbiology spectrum - 01 Nov 2018

Pizarro-Cerdá J, Cossart P

Link to Pubmed [PMID] – 30523778

Microbiol Spectr 2018 Nov;6(6)

The Gram-positive pathogen is able to promote its entry into a diverse range of mammalian host cells by triggering plasma membrane remodeling, leading to bacterial engulfment. Upon cell invasion, disrupts its internalization vacuole and translocates to the cytoplasm, where bacterial replication takes place. Subsequently, uses an actin-based motility system that allows bacterial cytoplasmic movement and cell-to-cell spread. therefore subverts host cell receptors, organelles and the cytoskeleton at different infection steps, manipulating diverse cellular functions that include ion transport, membrane trafficking, post-translational modifications, phosphoinositide production, innate immune responses as well as gene expression and DNA stability.

https://www.ncbi.nlm.nih.gov/pubmed/30523778