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Targeted norfloxacin is active in vivo against persistent Mycobacterium bovis BCG

Characterization of a cardiac-specific enhancer, which directs {alpha}-cardiac actin gene transcription in the mouse adult heart.

© Valérie Choumet

Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).

Publication : Nucleosides, nucleotides & nucleic acids

Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance

Team: Chemistry of Biomolecules

Member: Laurence Mulard

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in Nucleosides, nucleotides & nucleic acids - 01 Jan 2005

Alvarez K, Deval J, Selmi B, Barral K, Boretto J, Guerreiro C, Mulard L, Sarfati R, Canard B

Link to Pubmed [PMID] – 16247962

Nucleosides Nucleotides Nucleic Acids 2005;24(5-7):419-21

Alpha-boranophosphates suppress RT-mediated resistance when the catalytic rate of incorporation (kpol) of the analogue 5′-triphosphate is responsable for drug resistance, such as in the case of K65R mutant and ddNTPs, and Q151M toward AZTTP and ddNTPs. This suppression is also observed with BH3-d4T and BH3-3TC toward their clinically relevant mutants Q151M and M184V. Moreover, the presence of the borano (BH3-) group renders the incorporation of the analogue independent from amino-acid substitutions in RT. To our knowledge, this is the first example of rescue of polymerase activity by means of a nucleotide analogue.

Published on: 01 Jan 2005