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© Research
Publication : Biopolymers

Bisintercalation of ditercalinium into a d(CpGpApTpCpG)2 minihelix: a 1H- and 31P-NMR study

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biopolymers - 01 Dec 1989

Delepierre M, Dinh TH, Roques BP

Link to Pubmed [PMID] – 2605314

Biopolymers 1989 Dec;28(12):2115-42

The structure of the complex formed in aqueous solution between ditercalinium, a bisintercalating drug, and the self-complementary hexanucleotide d(CpGpApTpCpG)2 is investigated by 400-MHz 1H-nmr and 162-MHz 31P-nmr. Whatever the drug to helix ratio, ditercalinium occurred in the bound form, whereas free and complexed hexanucleotide are in slow exchange. This allows unambiguous resonance assignment through two-dimensional chemical exchange experiments. The strong upfield shifts measured on most aromatic protons on both drug and bases as well as on DNA imino protons are consistent with bisintercalation of the dimer. Nuclear Overhauser effects observed between drug and nucleotide protons give a defined geometry for complexation, and suggest a DNA conformational change upon drug binding.

http://www.ncbi.nlm.nih.gov/pubmed/2605314