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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Developmental cell

Bacterial invasion: a new strategy to dominate cytoskeleton plasticity

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Developmental cell - 01 Mar 2004

Cossart P

Link to Pubmed [PMID] – 15030752

Dev. Cell 2004 Mar;6(3):314-5

Some bacterial pathogens enter mammalian cells by injecting, directly into the host cytosol, proteins that trigger cytoskeletal rearrangements necessary for internalization. In the February 27 issue of Molecular Cell, McGhie et al. identify mechanisms by which the Salmonella protein SipA interferes with ADF/cofilin and gelsolin function. Thus Salmonella not only triggers actin polymerization but also counteracts the major F-actin destabilizing proteins.

http://www.ncbi.nlm.nih.gov/pubmed/15030752