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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : FEBS letters

Bacterial entry into cells: a role for the endocytic machinery

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in FEBS letters - 21 Apr 2006

Bonazzi M, Cossart P

Link to Pubmed [PMID] – 16650411

FEBS Lett. 2006 May;580(12):2962-7

Increasing evidence indicates that pathogens have evolved highly efficient strategies to induce their internalization within host cells. Viruses and bacteria express and expose on their surface, molecules that mimic endogenous ligands to cell receptors, thereby inducing specific intracellular signalling cascades. More recently it has become clear that, as most viruses, bacteria can enter cells via the clathrin-mediated pathway, indicating a key role for endocytosis in pathogens entry into cells. Here we review the pathways followed by Listeria monocytogenes to enter into non-phagocytic cells, as a model for the subversion of cellular functions to induce pathogens internalization.

http://www.ncbi.nlm.nih.gov/pubmed/16650411