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© Research
Publication : Antimicrobial agents and chemotherapy

Azole preexposure affects the Aspergillus fumigatus population in patients.

Team: Microbial Evolutionary Genomics
Member: Sylvain Brisse
Member: Alexandre Alanio
Member: Stéphane Bretagne
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 18 Jun 2012

Alanio A, Cabaret O, Sitterlé E, Costa JM, Brisse S, Cordonnier C, Bretagne S,

Link to Pubmed [PMID] – 22710122

Link to DOI – 10.1128/AAC.05990-11

Antimicrob. Agents Chemother. 2012 Sep; 56(9): 4948-50

The relationship between the azole preexposure of 86 patients and the genotype, azole susceptibility, and cyp51A polymorphisms of 110 corresponding Aspergillus fumigatus isolates was explored. Isolates carrying serial polymorphisms (F46Y and M172V with or without N248T with or without D255E with or without E427K) had higher itraconazole MICs (P = 0.04), although <2 μg/ml using the EUCAST methodology, were associated with two genetic clusters (P < 0.001) and with voriconazole preexposure of patients (P = 0.016). Voriconazole preexposure influences the distribution of A. fumigatus isolates with selection of isolates carrying cyp51A polymorphisms and higher itraconazole MICs.