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© Marion Coolen
Radial glia neural stem cells of the adult zebrafish telencephalon electroporated with a membrane tagged GFP
Publication : Gene expression patterns : GEP

atoh1.2 and beta3.1 are two new bHLH-encoding genes expressed in selective precursor cells of the zebrafish anterior hindbrain

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Gene expression patterns : GEP - 01 Nov 2004

Adolf B, Bellipanni G, Huber V, Bally-Cuif L

Link to Pubmed [PMID] – 15533816

Gene Expr. Patterns 2004 Nov;5(1):35-41

Transcription factors of the bHLH class play crucial roles in neurogenesis by controlling the location and timing of neuronal commitment and differentiation, as well as influencing neuronal identity. Proneural bHLH factors belong to the Olig, Neurogenin, NeuroD, Achaete-scute and Atonal subfamilies, and are expressed in partially overlapping or complementary patterns within the vertebrate embryonic neural tube. The combinatorial expression of these factors likely drives the generic and cell type-specific properties of neurogenesis throughout the nervous system. As an approach towards identifying a complete set of vertebrate proneural factors, we report here the isolation of two new zebrafish neural bHLH gene members, atoh1.2 and beta3.1. Among other sites, both are expressed in the late embryonic and early larval anterior hindbrain. In this territory we demonstrate that atoh1.2 and beta3.1 are transcribed in distinct precursors, further highlighting the subdivision of anterior zebrafish hindbrain into subdomains of bHLH expression.

http://www.ncbi.nlm.nih.gov/pubmed/15533816