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© Laurent Debarbieux
Bactériophages sur la bactérie Escherichia coli 0104:H4 souche 55989.
Publication : Virologie (Montrouge, France)

Antibacterial applications of bacteriophages.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Virologie (Montrouge, France) - 01 Feb 2020

Ansaldi M, Boulanger P, Brives C, Debarbieux L, Dufour N, Froissart R, Gandon S, Le Hénaff C, Petit MA, Rocha E, Torres-Barceló C,

Link to Pubmed [PMID] – 32108014

Link to DOI [DOI] – 10.1684/vir.2019.0805

Virologie (Montrouge) 2020 02; 24(1): 23-36

In the 1917 article in which Félix d’Hérelle describes his first observations and proposes the name of bacteriophage, he also reports the first use of these viruses to treat bacterial infections, thus giving birth to phage therapy. Soon after antibiotics supplanted bacteriophages. Today, bacteria resistant to multiple antibiotics become a growing public health issue worldwide. This situation has revived research aiming at developing the antibacterial activity of bacteriophages to treat patients as well as diseases in animals and plants. In fact, the areas of applications of bacteriophages as antibacterial are widening as current solutions of chemical nature are questioned. This review summarizes the basic principles of therapeutic applications of bacteriophages and presents recent data in areas where commercial exploitation is occurring or about to emerge.

https://pubmed.ncbi.nlm.nih.gov/32108014