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© Structural Dynamics Of Macromolecules
The structure of a bacterial analog of the nicotinic receptor (one color per subunit) inserted into the cell membrane (grey and orange). A representation of the volume accessible to ions is shown in yellow.
Publication : Curr. Op. Struct. Biol.

Aminoacyl-tRNA synthetases.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Curr. Op. Struct. Biol. - 01 Feb 1995

Delarue M.

Link to Pubmed [PMID] – 7773747

Link to DOI – 10.1016/0959-440x(95)80008-o

Curr Opin Struct Biol. 1995 Feb;5(1):48-55. Review.

Detailed mechanisms for each step of the reaction catalyzed by both class I and class II aminoacyl-tRNA synthetases have been proposed on the basis of crystallographic data of aminoacyl-tRNA synthetases in complex with their different substrates. Despite the very different topologies of the two classes, there are striking and unanticipated chemical similarities between their active sites and proposed mechanisms.