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© Research
Publication : Cell host & microbe

Actin’ on HIV: How Dendritic Cells Spread Infection

Team: Virus and Immunity
Member: Olivier Schwartz
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell host & microbe - 01 Mar 2016

Donahue DA, Schwartz O

Link to Pubmed [PMID] – 26962935

Cell Host Microbe 2016 Mar;19(3):267-9

Dendritic cells (DCs) capture HIV particles and transmit them to CD4 T cells. In a recent article published in Cell, Ménager and Littman (2016) perform an shRNA screen in DCs and find that actin nucleation and stabilization regulate HIV uptake and maintain the virus on membrane protrusions for efficient transfer.