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© Research
Publication : Scientific reports

A unified resource and configurable model of the synapse proteome and its role in disease.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Scientific reports - 11 May 2021

Sorokina O, Mclean C, Croning MDR, Heil KF, Wysocka E, He X, Sterratt D, Grant SGN, Simpson TI, Armstrong JD,

Link to Pubmed [PMID] – 33976238

Link to DOI – 996710.1038/s41598-021-88945-7

Sci Rep 2021 May; 11(1): 9967

Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct protein-protein interactions and functional metadata to build a network resource that reveals the shared and unique protein components that underpin multiple disorders. All the data are provided in a flexible and accessible format to encourage custom use.

https://pubmed.ncbi.nlm.nih.gov/33976238