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© Research
Publication : Nature Communications

3D mechanical characterization of single cells and small organisms using acoustic manipulation and force microscopy

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature Communications - 10 May 2021

Nino F Läubli, Jan T Burri, Julian Marquard, Hannes Vogler, Gabriella Mosca, Nadia Vertti-Quintero, Naveen Shamsudhin, Andrew deMello, Ueli Grossniklaus, Daniel Ahmed, Bradley J Nelson

Link to Pubmed [PMID] – 33972516

Link to DOI – 10.1038/s41467-021-22718-8

Nat Commun . 2021 May 10;12(1):2583

Quantitative micromechanical characterization of single cells and multicellular tissues or organisms is of fundamental importance to the study of cellular growth, morphogenesis, and cell-cell interactions. However, due to limited manipulation capabilities at the microscale, systems used for mechanical characterizations struggle to provide complete three-dimensional coverage of individual specimens. Here, we combine an acoustically driven manipulation device with a micro-force sensor to freely rotate biological samples and quantify mechanical properties at multiple regions of interest within a specimen. The versatility of this tool is demonstrated through the analysis of single Lilium longiflorum pollen grains, in combination with numerical simulations, and individual Caenorhabditis elegans nematodes. It reveals local variations in apparent stiffness for single specimens, providing previously inaccessible information and datasets on mechanical properties that serve as the basis for biophysical modelling and allow deeper insights into the biomechanics of these living systems.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8110787/