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Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome

A casein kinase II phosphorylation site in the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor determines the high affinity interaction of the AP-1 Golgi assembly proteins with membranes.

© Research

Publication : Mammalian genome : official journal of the International Mammalian Genome Society

A high-resolution map around the locus Om on mouse Chromosome 11

Team: Early Mammalian Development & Stem Cell Biology

Team: Archived: Mouse Functional Genetics

Member: Michel Cohen-Tannoudji

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Diseases

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Published in Mammalian genome : official journal of the International Mammalian Genome Society - 01 Feb 1996

Baldacci PA, Cohen-Tannoudji M, Kress C, Pournin S, Babinet C

Link to Pubmed [PMID] – 8835527

Mamm. Genome 1996 Feb;7(2):114-6

The locus Om (ovum mutant) identified in the mouse strain DDK affects the viability of (DDK x non-DDK)F1 preimplantation embryos. We previously located this locus on Chromosome (Chr) 11 close to Scya2 (Baldacci et al. Mamm. Genome 2, 100-105, 1992). Here we report a high-resolution map of the region around Om based on a large number of backcross individuals. The same region has been analyzed on the EUCIB backcross, and the two maps have been compared. The results define the proximal and distal boundaries for the Om mutation as Scya2 and D11Mit36 respectively. The distance between these two markers is about 2 cM. These data should facilitate the positional cloning and molecular characterization of Om.

Published on: 01 Feb 1996