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© Research
Publication : Nature immunology

A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature immunology - 18 Oct 2021

Andreakos E, Abel L, Vinh DC, Kaja E, Drolet BA, Zhang Q, O'Farrelly C, Novelli G, Rodríguez-Gallego C, Haerynck F, Prando C, Pujol A, , Su HC, Casanova JL, Spaan AN,

Link to Pubmed [PMID] – 34667308

Link to DOI – 10.1038/s41590-021-01030-z

Nat Immunol 2021 Oct; ():

SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological determinants of resistance to infection per se remain unknown. Following the discovery that autosomal recessive deficiency in the DARC chemokine receptor confers resistance to Plasmodium vivax, autosomal recessive deficiencies of chemokine receptor 5 (CCR5) and the enzyme FUT2 were shown to underlie resistance to HIV-1 and noroviruses, respectively. Along the same lines, we propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.

https://pubmed.ncbi.nlm.nih.gov/34667308