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© Research
Publication : Cold Spring Harbor perspectives in medicine

A genome-wide perspective of human diversity and its implications in infectious disease

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cold Spring Harbor perspectives in medicine - 01 Jan 2013

Manry J, Quintana-Murci L

Link to Pubmed [PMID] – 23284079

Cold Spring Harb Perspect Med 2013 Jan;3(1):a012450

Progress in genomic technologies, such as DNA arrays and next-generation sequencing, is allowing systematic characterization of the degree of human genetic variation at the scale of individual genomes. Public efforts, such as the International HapMap Project and the 1000 Genomes Project, have provided a realistic picture of the levels of genetic diversity in individuals and populations. These genomic techniques are also making it possible to evaluate the contribution of host genetic diversity to differences in susceptibility to both rare and common infectious diseases. Recent studies have revealed the power of whole-exome sequencing for dissecting the immunological mechanisms underlying the pathogenesis of severe, rare infectious diseases. Likewise, genome-wide association studies on common viral, bacterial, and parasitic infections have shed light on the host genetic basis of susceptibility to infectious diseases and, in some cases, of disease progression and drug responses.

http://www.ncbi.nlm.nih.gov/pubmed/23284079