• 2025
  Boullé M. and Agou F., Semi-automated detection of Late Cytokinetic Bridges, Methods Mol Biol..
• 2025
  Jean Guillon, Solène Savrimoutou, Nicolas da Rocha, Sandra Albenque-Rubio, Olivier Helynck, Cyrielle Durand, Jeanne Chiaravalli, Noël Pinaud, Luisa Ronga, Stéphane Moreau, Simon Chirold, Tshering Zangmo, Melika Arab, Lindita Lari, Jean‐louis Mergny, Hélène Munier-Lehmann, Marc Lavigne, Design, synthesis, biophysical and biological evaluation of original condensed pyrrolopyrimidine and pyrrolopyridine ligands as anti-SARS-CoV-2 agents targeting G4, European Journal of Medicinal Chemistry, 2025, 292, pp.117655. ⟨10.1016/j.ejmech.2025.117655⟩.
• 2025
  Tim Krischuns, Sylvain Paisant, Kuang-Yu Chen, Laura N. Thirion, Agnès Zettor, Jeanne Chiaravalli, Yves Jacob, Marco Bellinzoni, Nadia Naffakh, Yves L. Janin, Noncovalent Inhibitors of SARS-CoV-2 Main Protease: A Rescaffolding Attempt, Synthesis.
• 2024
  Barbachowska M, Harivel T, Nicchi S, Danckaert A, Ghazarian M, Chiaravalli J, Buchrieser C, Rolando M, Arimondo PB, High Content Screening Assay of Inhibitors of the Legionella Pneumophila Histone Methyltransferase RomA in Infected Cells., Chembiochem 2024 Dec; 25(23): e202400293.
• 2024
  Boullé M, Leleu A, Schacre S, Banal C, Boucharlat A, Renault S, Hollenstein M, Frosk P, Yates F, Lefort N, Agou F, Generation of IPi002-A/B/C human induced pluripotent stem cell lines from MARCH amniotic fluid cells., Stem Cell Res 2024 Oct; 81(): 103589.
• 2024
  Khan S, Partuk EO, Chiaravalli J, Kozer N, Shurrush KA, Elbaz-Alon Y, Scher N, Giraud E, Tran-Rajau J, Agou F, Barr HM, Avinoam O, High-throughput screening identifies broad-spectrum Coronavirus entry inhibitors., iScience 2024 Jun; 27(6): 110019.
• 2024
  Boullé M, Boucharlat A, Leleu A, Banal C, Coussement A, Hollenstein M, Yates F, Lefort N, Agou F, Generation of IPi001-A/B/C human induced pluripotent stem cell lines from healthy amniotic fluid cells., Stem Cell Res 2024 Apr; 76(): 103350.
• 2024
  Yang L, Jasiqi Y, Zettor A, Vadas O, Chiaravalli J, Agou F, Lashuel HA, Effective Inhibition of TDP-43 Aggregation by Native State Stabilization., Angew Chem Int Ed Engl 2024 Jan; 63(3): e202314587.
• 2024
  Martinez FJ, White M, Guillotte-Blisnick M, Huon C, Boucharlat A, Agou F, England P, Popovici J, Hou MM, Silk SE, Barrett JR, Nielsen CM, Reimer JM, Mukherjee P, Chauhan VS, Minassian AM, Draper SJ, Chitnis CE, PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial., NPJ Vaccines 2024 Jan; 9(1): 10.
• 2024
  Giraud E, Fiette L, Melanitou E, Type 1 diabetes and parasite infection: An exploratory study in NOD mice., PLoS One 2024 ; 19(10): e0308868.
• 2023
  Billet A, Hadjerci J, Tran T, Kessler P, Ulmer J, Mourier G, Ghazarian M, Gonzalez A, Thai R, Urquia P, Van Baelen AC, Meola A, Fernandez I, Deville-Foillard S, MacDonald E, Paolini L, Schmidt F, Rey FA, Kay MS, Tartour E, Servent D, Johannes L, A synthetic delivery vector for mucosal vaccination., Biomaterials 2023 Sep; 302(): 122298.
• 2023
  de Melo GD, Perraud V, Alvarez F, Vieites-Prado A, Kim S, Kergoat L, Coleon A, Trüeb BS, Tichit M, Piazza A, Thierry A, Hardy D, Wolff N, Munier S, Koszul R, Simon-Lorière E, Thiel V, Lecuit M, Lledo PM, Renier N, Larrous F, Bourhy H, Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants., Nat Commun 2023 Jul; 14(1): 4485.
• 2023
  Broketa M, Sokal A, Mor M, Canales-Herrerias P, Perima A, Meola A, Fernández I, Iannascoli B, Chenon G, Vandenberghe A, Languille L, Michel M, Godeau B, Gallien S, Melica G, Backovic M, Rey FA, Baudry J, Freund NT, Mahévas M, Bruhns P, Qualitative monitoring of SARS-CoV-2 mRNA vaccination in humans using droplet microfluidics., JCI Insight 2023 Jul; 8(13): .
• 2023
  Murray GPD, Giraud E, Hol FJH, Characterizing Mosquito Biting Behavior at High Resolution., Cold Spring Harb Protoc 2023 Jul; 2023(7): .pdb.top107658.
• 2023
  Murray GPD, Giraud E, Hol FJH, Characterizing Mosquito Biting Behavior Using the BiteOscope., Cold Spring Harb Protoc 2023 Jul; 2023(7): .pdb.prot108176.
• 2023
  Giraud É, Milon G, [Elucidating and characterizing the dynamic biological processes that account for the sustainability of Leishmania populations]., Med Trop Sante Int 2023 Jun; 3(2): .
• 2023
  Gedeon A, Ayoub N, Brûlé S, Raynal B, Karimova G, Gelin M, Mechaly A, Haouz A, Labesse G, Munier-Lehmann H, Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs., Protein Sci 2023 Jun; (): e4703.
• 2023
  Touret F, Giraud E, Bourret J, Donati F, Tran-Rajau J, Chiaravalli J, Lemoine F, Agou F, Simon-Lorière E, van der Werf S, de Lamballerie X, Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 omicron sub-lineages., iScience 2023 Apr; 26(4): 106413.
• 2023
  Hellert J, Aebischer A, Haouz A, Guardado-Calvo P, Reiche S, Beer M, Rey FA, Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein., Cell Rep 2023 Mar; 42(3): 112142.
• 2023
  Hassan H, Chiavaralli J, Hassan A, Bedda L, Krischuns T, Chen KY, Li ASM, Delpal A, Decroly E, Vedadi M, Naffakh N, Agou F, Mallart S, Arafa RK, Arimondo PB, , Design and synthesis of naturally-inspired SARS-CoV-2 inhibitors., RSC Med Chem 2023 Mar; 14(3): 507-519.
• 2023
  Gedeon A, Karimova G, Ayoub N, Dairou J, Giai Gianetto Q, Vichier-Guerre S, Vidalain PO, Ladant D, Munier-Lehmann H, Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli., FEBS J 2023 Feb; (): .
• 2022
  Mikaël Boullé,* Laurianne Davignon, Keïs Nabhane Saïd Halidi, Salomé Guez, Emilie Giraud, Marcel Hollenstein, and Fabrice Agou*, High-Content RNAi Phenotypic Screening Unveils the Involvement of Human Ubiquitin-Related Enzymes in Late Cytokinesis, Cells 2022, 11(23), 3862.
• 2022
  Planchais C, Fernández I, Bruel T, de Melo GD, Prot M, Beretta M, Guardado-Calvo P, Dufloo J, Molinos-Albert LM, Backovic M, Chiaravalli J, Giraud E, Vesin B, Conquet L, Grzelak L, Planas D, Staropoli I, Guivel-Benhassine F, Hieu T, Boullé M, Cervantes-Gonzalez M, Ungeheuer MN, Charneau P, van der Werf S, Agou F, , , Dimitrov JD, Simon-Lorière E, Bourhy H, Montagutelli X, Rey FA, Schwartz O, Mouquet H, Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2., J Exp Med 2022 Jul; 219(7): .
• 2022
  Chen KY, Krischuns T, Varga LO, Harigua-Souiai E, Paisant S, Zettor A, Chiaravalli J, Delpal A, Courtney D, O'Brien A, Baker SC, Decroly E, Isel C, Agou F, Jacob Y, Blondel A, Naffakh N, , A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors., Antiviral Res 2022 May; 201(): 105272.
• 2022
  Si Y, Bon C, Barbachowska M, Cadet-Daniel V, Jallet C, Soresinetti L, Boullé M, Duchateau M, Matondo M, Agou F, Halby L, Arimondo PB, , A novel screening strategy to identify histone methyltransferase inhibitors reveals a crosstalk between DOT1L and CARM1., RSC Chem Biol 2022 Apr; 3(4): 456-467.
• 2022
  Giraud É, Varet H, Legendre R, Sismeiro O, Aubry F, Dabo S, Dickson LB, Valiente Moro C, Lambrechts L, Mosquito-bacteria interactions during larval development trigger metabolic changes with carry-over effects on adult fitness., Mol Ecol 2022 Mar; 31(5): 1444-1460.
• 2021
  Oshchepkov AS, Reznichenko O, Xu D, Morozov BS, Granzhan A, Kataev EA, , Dye-functionalized phosphate-binding macrocycles: from nucleotide to G-quadruplex recognition and “turn-on” fluorescence sensing., Chem Commun (Camb) 2021 Sep; (): .
• 2021
  Anca F. Savulescu, Robyn Brackin, Emmanuel Bouilhol, Benjamin Dartigues, Jonathan H. Warrell, Mafalda R. Pimentel, Nicolas Beaume, Isabela C. Fortunato, Stephane Dallongeville, Mikaël Boullé, Hayssam Soueidan, Fabrice Agou, Jan Schmoranzer, Jean-Christophe Olivo-Marin, Claudio A. Franco, Edgar R. Gomes, Macha Nikolski, and Musa M. Mhlanga , Interrogating RNA and protein spatial subcellular distribution in smFISH data with DypFISH, Volume 1, Issue 5, 27 September 2021, 100068.
• 2021
  Meyer B, Chiaravalli J, Gellenoncourt S, Brownridge P, Bryne DP, Daly LA, Grauslys A, Walter M, Agou F, Chakrabarti LA, Craik CS, Eyers CE, Eyers PA, Gambin Y, Jones AR, Sierecki E, Verdin E, Vignuzzi M, Emmott E, , Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential., Nat Commun 2021 09; 12(1): 5553.
• 2021
  Zahradník J, Marciano S, Shemesh M, Zoler E, Harari D, Chiaravalli J, Meyer B, Rudich Y, Li C, Marton I, Dym O, Elad N, Lewis MG, Andersen H, Gagne M, Seder RA, Douek DC, Schreiber G, , SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution., Nat Microbiol 2021 09; 6(9): 1188-1198.
• 2021
  Lavigne M, Helynck O, Rigolet P, Boudria-Souilah R, Nowakowski M, Baron B, Brülé S, Hoos S, Raynal B, Guittat L, Beauvineau C, Petres S, Granzhan A, Guillon J, Pratviel G, Teulade-Fichou MP, England P, Mergny JL, Munier-Lehmann H, SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction., Nucleic Acids Res 2021 Jul; 49(13): 7695-7712.
• 2021
  Kastan N, Gnedeva K, Alisch T, Petelski AA, Huggins DJ, Chiaravalli J, Aharanov A, Shakked A, Tzahor E, Nagiel A, Segil N, Hudspeth AJ, , Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues., Nat Commun 2021 05; 12(1): 3100.
• 2021
  Giraud E, Del Val CO, Caillet-Saguy C, Zehrouni N, Khou C, Caillet J, Jacob Y, Pardigon N, Wolff N, Role of PDZ-binding motif from West Nile virus NS5 protein on viral replication., Sci Rep 2021 Feb; 11(1): 3266.
• 2021
  Reznichenko O, Cucchiarini A, Gabelica V, Granzhan A, , Quadruplex DNA-guided ligand selection from dynamic combinatorial libraries of acylhydrazones., Org Biomol Chem 2021 01; 19(2): 379-386.
• 2020
  Olivier Borkowski, Mathilde Koch, Agnès Zettor, Amir Pandi, Angelo Cardoso Batista, Paul Soudier, Jean-Loup Faulon, Large Scale Active-Learning-Guided Exploration for in Vitro Protein Production Optimization, Nat Commun. 2020 Apr 20;11(1):1872.
• 2019
  Karine Nozeret, Alix Boucharlat, Fabrice Agou, Nienke Buddelmeijer, A sensitive fluorescence-based assay to monitor enzymatic activity of the essential integral membrane protein Apolipoprotein N-acyltransferase (Lnt), Scientific Reports, 2019, 9 (1), pp.15978. ⟨10.1038/s41598-019-52106-8⟩.
• 2019
  Said Halidi KN, Fontan E, Boucharlat A, Davignon L, Charpentier M, Boullé M, Weil R, Israël A, Laplantine E, Agou F., Two NEMO-like Ubiquitin-Binding Domains in CEP55 Differently Regulate Cytokinesis., iScience. 2019 Sep 25;20:292-309.
• 2019
  Reznichenko O, Quillévéré A, Martins RP, Loaëc N, Kang H, Lista MJ, Beauvineau C, González-García J, Guillot R, Voisset C, Daskalogianni C, Fåhraeus R, Teulade-Fichou MP, Blondel M, Granzhan A, , Novel cationic bis(acylhydrazones) as modulators of Epstein-Barr virus immune evasion acting through disruption of interaction between nucleolin and G-quadruplexes of EBNA1 mRNA., Eur J Med Chem 2019 Sep; 178(): 13-29.
• 2019
  Giraud E, Rouault E, Fiette L, Colle JH, Smirlis D, Melanitou E, Osteopontin in the host response to Leishmania amazonensis., BMC Microbiol 2019 Feb; 19(1): 32.
• 2018
  Xie X, Reznichenko O, Chaput L, Martin P, Teulade-Fichou MP, Granzhan A, , Topology-Selective, Fluorescent “Light-Up” Probes for G-Quadruplex DNA Based on Photoinduced Electron Transfer., Chemistry 2018 Aug; 24(48): 12638-12651.
• 2018
  Charpentier M, Khedher AHY, Menoret S, Brion A, Lamribet K, Dardillac E, Boix C, Perrouault L, Tesson L, Geny S, De Cian A, Itier JM, Anegon I, Lopez B, Giovannangeli C and Concordet JP, CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair., Nat Commun. 2018 Mar 19;9(1):1133.
• 2018
  Vincenzo Di Donato, Flavia De Santis, Shahad Albadri, Thomas Oliver Auer, Karine Duroure, Marine Charpentier, Jean-Paul Concordet, Christoph Gebhardt, and Filippo Del Bene, An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System, Neuron. 2018 Feb 5. pii: S0896-6273(18)30055-2..
• 2018
  Valentine Mosbach, Lucie Poggi, David Viterbo, Marine Charpentier and Guy-Franck Richard, TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats., Cell Rep. 2018 Feb 20;22(8):2146-2159.
• 2017
  Eckenfelder A, Ségéral E, Pinzón N, Ulveling D, Amadori C, Charpentier M, Nidelet S, Concordet JP, Zagury JF, Paillart JC, Berlioz-Torrent C, Seitz H, Emiliani S, Gallois-Montbrun S, Argonaute proteins regulate HIV-1 multiply spliced RNA and viral production in a Dicer independent manner, Nucleic Acids Res. 2017 Apr;45(7):4158-4173.
• 2017
  Bal E, Laplantine E, Hamel Y, Dubosclard V, Boisson B, Pescatore A, Picard C, Hadj-Rabia S, Royer G, Steffann J, Bonnefont JP, Ursini VM, Vabres P, Munnich A, Casanova JL, Bodemer C, Weil R, Agou F, Smahi A, Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-κB activation and leads to incontinentia pigmenti., J Allergy Clin Immunol. 2017 Dec;140(6):1671-1682.e2.
• 2017
  Mahamed D, Boulle M, Ganga Y, Mc Arthur C, Skroch S, Oom L, Catinas O, Pillay K, Naicker M, Rampersad S, Mathonsi C, Hunter J, Wong EB, Suleman M, Sreejit G, Pym AS, Lustig G, Sigal A, Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells., Elife. 2017 May 5;6. pii: e28205.
• 2017
  Phillips AF, Millet AR, Tigano M, Dubois SM, Crimmins H, Babin L, Charpentier M, Piganeau M, Brunet E, Sfeir A, Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion, Mol. Cell 2017 Feb;65(3):527-538.e6.
• 2016
  Boullé M, Müller TG, Dähling S, Ganga Y, Jackson L, Mahamed D, Oom L, Lustig G, Neher RA, Sigal A, HIV Cell-to-Cell Spread Results in Earlier Onset of Viral Gene Expression by Multiple Infections per Cell, PLoS Pathog. 2016 Nov 3;12(11):e1005964.
• 2016
  Janine Scholefield, Ricardo Henriques, Anca Savulescu, Elisabeth Fontan, Alix F Boucharlat, Emmanuel Laplantine, Asma Smahi, Alain Israël, Fabrice Agou, Musa M Mhlanga, Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti, Nature Communications, 2016, 7, pp.12629. ⟨10.1038/ncomms12629⟩.
• 2016
  Gammage PA, Gaude E, Van Haute L, Rebelo-Guiomar P, Jackson CB, Rorbach J, Pekalski ML, Robinson AJ, Charpentier M, Concordet JP, Frezza C, Minczuk M, Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs, Nucleic Acids Res. 2016 Sep;44(16):7804-16.
• 2016
  Böhm UL, Prendergast A, Djenoune L, Nunes Figueiredo S, Gomez J, Stokes C, Kaiser S, Suster M, Kawakami K, Charpentier M, Concordet JP, Rio JP, Del Bene F, Wyart C, CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits, Nat Commun 2016 Mar;7:10866.
• 2016
  Renaud JB, Boix C, Charpentier M, De Cian A, Cochennec J, Duvernois-Berthet E, Perrouault L, Tesson L, Edouard J, Thinard R, Cherifi Y, Menoret S, Fontanière S, de Crozé N, Fraichard A, Sohm F, Anegon I, Concordet JP, Giovannangeli C, Improved Genome Editing Efficiency and Flexibility Using Modified Oligonucleotides with TALEN and CRISPR-Cas9 Nucleases, Cell Rep 2016 Mar;14(9):2263-72.
• 2015
  Dubosclard V, Fontan E, Agou F, Use of fluorescence spectroscopy for quantitative investigations of ubiquitin interactions with the ubiquitin-binding domains of NEMO, Methods Mol. Biol. 2015;1280:321-37.
• 2015
  Agou F, Véron M, In vivo protein cross-linking, Methods Mol. Biol. 2015;1278:391-405.
• 2014
  Remy S, Tesson L, Menoret S, Usal C, De Cian A, Thepenier V, Thinard R, Baron D, Charpentier M, Renaud JB, Buelow R, Cost GJ, Giovannangeli C, Fraichard A, Concordet JP, Anegon I, Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases, Genome Res. 2014 Aug;24(8):1371-83.
• 2014
  Tarantino N, Tinevez JY, Crowell EF, Boisson B, Henriques R, Mhlanga M, Agou F, Israël A, Laplantine E, , TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures., J Cell Biol 2014 Jan; 204(2): 231-45.
• 2013
  Ngadjeua F, Chiaravalli J, Traincard F, Raynal B, Fontan E, Agou F, Two-sided ubiquitin binding of NF-κB essential modulator (NEMO) zinc finger unveiled by a mutation associated with anhidrotic ectodermal dysplasia with immunodeficiency syndrome, J. Biol. Chem. 2013 Nov;288(47):33722-37.
• 2011
  Chiaravalli J, Fontan E, Fsihi H, Coic YM, Baleux F, Véron M, Agou F, Direct inhibition of NF-κB activation by peptide targeting the NOA ubiquitin binding domain of NEMO, Biochem. Pharmacol. 2011 Nov;82(9):1163-74.
• 2011
  Rameix-Welti MA, Munier S, Le Gal S, Cuvelier F, Agou F, Enouf V, Naffakh N, van der Werf S, , Neuraminidase of 2007-2008 influenza A(H1N1) viruses shows increased affinity for sialic acids due to the D344N substitution., Antivir Ther 2011 ; 16(4): 597-603.
• 2009
  Grubisha O, Kaminska M, Duquerroy S, Fontan E, Cordier F, Haouz A, Raynal B, Chiaravalli J, Delepierre M, Israël A, Véron M, Agou F, DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding, J. Mol. Biol. 2010 Jan;395(1):89-104.
• 2008
  Cordier F, Grubisha O, Traincard F, Véron M, Delepierre M, Agou F, The zinc finger of NEMO is a functional ubiquitin-binding domain, J. Biol. Chem. 2009 Jan;284(5):2902-7.
• 2008
  Cordier F, Vinolo E, Véron M, Delepierre M, Agou F, Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation, J. Mol. Biol. 2008 Apr;377(5):1419-32.
• 2007
  Wyler E, Kaminska M, Coïc YM, Baleux F, Véron M, Agou F, Inhibition of NF-kappaB activation with designed ankyrin-repeat proteins targeting the ubiquitin-binding/oligomerization domain of NEMO, Protein Sci. 2007 Sep;16(9):2013-22.
• 2007
  Fontan E, Traincard F, Levy SG, Yamaoka S, Véron M, Agou F, NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex, FEBS J. 2007 May;274(10):2540-51.
• 2004
  Agou F, Traincard F, Vinolo E, Courtois G, Yamaoka S, Israël A, Véron M, The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains, J. Biol. Chem. 2004 Jul;279(27):27861-9.
• 2004
  Agou F, Ye F, Véron M, In vivo protein cross-linking, Methods Mol. Biol. 2004;261:427-42.