• 2024
  Cochet M, Piumi F, Gorna K, Berry N, Gonzalez G, Danckaert A, Aulner N, Blanchet O, Zientara S, Donadeu FX, Munier-Lehmann H, Richardson J, Benchoua A, Coulpier M, An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus., Vet Res 2024 Mar; 55(1): 32.
• 2024
  Ayoub N, Gedeon A, Munier-Lehmann H, A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis., Front Pharmacol 2024 ; 15(): 1329011.
• 2023
  Collados Rodríguez M, Maillard P, Journeaux A, Komarova AV, Najburg V, David RS, Helynck O, Guo M, Zhong J, Baize S, Tangy F, Jacob Y, Munier-Lehmann H, Meurs EF, Novel Antiviral Molecules against Ebola Virus Infection., Int J Mol Sci 2023 Sep; 24(19): .
• 2023
  Mauro E, Lapaillerie D, Tumiotto C, Charlier C, Martins F, Sousa SF, Métifiot M, Weigel P, Yamatsugu K, Kanai M, Munier-Lehmann H, Richetta C, Maisch M, Dutrieux J, Batisse J, Ruff M, Delelis O, Lesbats P, Parissi V, Modulation of the functional interfaces between retroviral intasomes and the human nucleosome., mBio 2023 Aug; 14(4): e0108323.
• 2023
  Gedeon A, Ayoub N, Brûlé S, Raynal B, Karimova G, Gelin M, Mechaly A, Haouz A, Labesse G, Munier-Lehmann H, Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs., Protein Sci 2023 Jun; (): e4703.
• 2023
  Gedeon A, Karimova G, Ayoub N, Dairou J, Giai Gianetto Q, Vichier-Guerre S, Vidalain PO, Ladant D, Munier-Lehmann H, Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli., FEBS J 2023 Feb; (): .
• 2023
  Zhou Z, Staropoli I, Brelot A, Suzanne P, Lesnard A, Fontaine F, Perato S, Rault S, Helynck O, Arenzana-Seisdedos F, Sopkova-de Oliveira Santos J, Lagane B, Munier-Lehmann H, Colin P, Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands., Molecules 2023 Jan; 28(3): .
• 2023
  Cioetto-Mazzabò L, Boldrin F, Beauvineau C, Speth M, Marina A, Namouchi A, Segafreddo G, Cimino M, Favre-Rochex S, Balasingham S, Trastoy B, Munier-Lehmann H, Griffiths G, Gicquel B, Guerin ME, Manganelli R, Alonso-Rodríguez N, , SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression., Nucleic Acids Res 2023 Jan; 51(1): 144-165.
• 2022
  Magnotti F, Chirita D, Dalmon S, Martin A, Bronnec P, Sousa J, Helynck O, Lee W, Kastner DL, Chae JJ, McDermott MF, Belot A, Popoff M, Sève P, Georgin-Lavialle S, Munier-Lehmann H, Tran TA, De Langhe E, Wouters C, Jamilloux Y, Henry T, , Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism., Cell Rep 2022 Oct; 41(2): 111472.
• 2022
  S. Temmam, K. Vongphayloth, E. Baquero Salazar, S. Munier⋆, M. Bonomi, et al., Discovery of bat coronaviruses close to SARS-CoV-2 and infectious for human cells., Nautre 604 (2022) 330.
• 2022
  Walter P, Mechaly A, Bous J, Haouz A, England P, Lai-Kee-Him J, Ancelin A, Hoos S, Baron B, Trapani S, Bron P, Labesse G, Munier-Lehmann H, , Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target., FEBS J 2022 Feb; (): .
• 2021
  Song L, Merceron R, Hulpia F, Lucía A, Gracia B, Jian Y, Risseeuw MDP, Verstraelen T, Cos P, Aínsa JA, Boshoff HI, Munier-Lehmann H, Savvides SN, Van Calenbergh S, , Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors., Eur J Med Chem 2021 Dec; 225(): 113784.
• 2021
  Lavigne M, Helynck O, Rigolet P, Boudria-Souilah R, Nowakowski M, Baron B, Brülé S, Hoos S, Raynal B, Guittat L, Beauvineau C, Petres S, Granzhan A, Guillon J, Pratviel G, Teulade-Fichou MP, England P, Mergny JL, Munier-Lehmann H, SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction., Nucleic Acids Res 2021 Jul; 49(13): 7695-7712.
• 2021
  Jian Y, Forbes HE, Hulpia F, Risseeuw MDP, Caljon G, Munier-Lehmann H, Boshoff HIM, Van Calenbergh S, , 2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F420)-Dependent Nitroreductase (Ddn)., J Med Chem 2021 01; 64(1): 440-457.
• 2020
  Jian Y, Merceron R, De Munck S, Forbes HE, Hulpia F, Risseeuw MDP, Van Hecke K, Savvides SN, Munier-Lehmann H, Boshoff HIM, Van Calenbergh S, , Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents., Eur J Med Chem 2020 Nov; 206(): 112659.
• 2020
  Thieulent C, Hue E, Sutton G, Fortier C, Dallemagne P, Zientara S, Munier-Lehmann H, Hans A, Paillot R, Vidalain PO, Pronost S, , Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: efficacy of decitabine and valganciclovir alone or in combination., Antiviral Res. 2020 Sep; (): 104931.
• 2020
  Jian Y, Hulpia F, Risseeuw MDP, Forbes HE, Munier-Lehmann H, Caljon G, Boshoff HIM, Van Calenbergh S, , Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents., Eur J Med Chem 2020 Sep; 201(): 112450.
• 2020
  Valle-Casuso JC, Gaudaire D, Martin-Faivre L, Madeline A, Dallemagne P, Pronost S, Munier-Lehmann H, Zientara S, Vidalain PO, Hans A, , Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors., Sci Rep 2020 Jun; 10(1): 10100.
• 2020
  Jian Y, Hulpia F, D P Risseeuw M, Forbes HE, Caljon G, Munier-Lehmann H, I M Boshoff H, Van Calenbergh S, , 1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors., Molecules 2020 Jun; 25(12): .
• 2020
  Encarnação JC, Napolitano V, Opassi G, Danielson UH, Dubin G, Popowicz GM, Munier-Lehmann H, Buijs J, Andersson K, Björkelund H, , A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells., FEBS Lett. 2020 May; (): .
• 2019
  Jian Y, Risseeuw MDP, Froeyen M, Song L, Cappoen D, Cos P, Munier-Lehmann H, van Calenbergh S, , 1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase., J Enzyme Inhib Med Chem 2019 Dec; 34(1): 1730-1739.
• 2019
  Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugué L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H, First-in-class allosteric inhibitors of bacterial IMPDHs, Eur J Med Chem 2019 Feb;167:124-132.
• 2019
  Thieulent CJ, Hue ES, Fortier CI, Dallemagne P, Zientara S, Munier-Lehmann H, Hans A, Fortier GD, Pitel PH, Vidalain PO, Pronost SL, Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay, Virology 2019 01;526:105-116.
• 2018
  Laskaris P, Vicentefranqueira R, Helynck O, Jouvion G, Calera JA, du Merle L, Suzenet F, Buron F, de Sousa RA, Mansuy D, Cavaillon JM, Latgé JP, Munier-Lehmann H, Ibrahim-Granet O, A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism, Antimicrob. Agents Chemother. 2018 Jun;62(6).
• 2018
  Song L, Merceron R, Gracia B, Quintana AL, Risseeuw MDP, Hulpia F, Cos P, Aínsa JA, Munier-Lehmann H, Savvides SN, Van Calenbergh S, Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors, J. Med. Chem. 2018 Apr;61(7):2753-2775.
• 2018
  Harigua-Souiai E, Abdelkrim YZ, Bassoumi-Jamoussi I, Zakraoui O, Bouvier G, Essafi-Benkhadir K, Banroques J, Desdouits N, Munier-Lehmann H, Barhoumi M, Tanner NK, Nilges M, Blondel A, Guizani I, Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A, PLoS Negl Trop Dis 2018 01;12(1):e0006160.
• 2018
  Suthagar K, Jiao W, Munier-Lehmann H, Fairbanks AJ, Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis, Carbohydr. Res. 2018 Mar;457:32-40.
• 2017
  Dabo S., Maillard P., Collados Rodriguez M., Hansen M. D., Mazouz S., Bigot D. J., Tible M., Janvier G., Helynck O., Cassonnet P., Jacob Y., Bellalou J., Gatignol A., Patel R. C., Hugon J., Munier-Lehmann H., Meurs E. F., Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT, Sci Rep. 2017 Nov 23;7(1):16129.
• 2017
  Buchieri MV, Cimino M, Rebollo-Ramirez S, Beauvineau C, Cascioferro A, Favre-Rochex S, Helynck O, Naud-Martin D, Larrouy-Maumus G, Munier-Lehmann H, Gicquel B, Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis, J. Med. Chem. 2017 Sep 14;60(17):7425-7433.
• 2017
  Lucas-Hourani M, Dauzonne D, Munier-Lehmann H, Khiar S, Nisole S, Dairou J, Helynck O, Afonso PV, Tangy F, Vidalain PO, Original chemical series of pyrimidine biosynthesis inhibitors that boost the antiviral interferon response, Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00383-17.
• 2017
  Koseki Y, Kanetaka H, Tsunosaki J, Munier-Lehmann H, Aoki S, Tetrahydro-2-furanyl-2,4(1H,3H)-pyrimidinedione derivatives as novel antibacterial compounds against Mycobacterium, Int. J. Mycobacteriol. 2017 Jan-Mar;6(1):61-69.
• 2016
  Song L, Risseeuw MDP, Froeyen M, Karalic I, Goeman J, Cappoen D, Van der Eycken J, Cos P, Munier-Lehmann H, Van Calenbergh S, Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents, Bioorg. Med. Chem. 2016 11;24(21):5172-5182.
• 2016
  Laskaris P, Atrouni A, Calera JA, d'Enfert C, Munier-Lehmann H, Cavaillon JM, Latgé JP, Ibrahim-Granet O., Administration of zinc chelators improves survival of mice infected with Aspergillus fumigatus both in monotherapy and in combination with caspofungin., Antimicrob Agents Chemother. 2016 Jul 11.
• 2016
  Adamska A, Rumijowska-Galewicz A, Ruszczynska A, Studzińska M, Jabłońska A, Paradowska E, Bulska E, Munier-Lehmann H, Dziadek J, Leśnikowski ZJ, Olejniczak AB, Anti-mycobacterial activity of thymine derivatives bearing boron clusters, Eur J Med Chem 2016 Oct;121:71-81.
• 2016
  Grandin C, Hourani ML, Janin YL, Dauzonne D, Munier-Lehmann H, Paturet A, Taborik F, Vabret A, Contamin H, Tangy F, Vidalain PO, Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors, Antiviral Res. 2016 Jan;125:58-62.
• 2016
  Stéphanie Petrella, Alexandra Aubry, Geneviève Janvier, Eloi Paul Coutant, Alex Cartier, Thuy-Ha Dao, Frédéric Bonhomme, Laurence Motreff, Cédric Pissis, Chantal Bizet, Dominique Clermont, Evelyne Begaud, Pascal Retailleau, Hélène Munier-Lehmann, Estelle Capton, Claudine Mayer, Yves Janin, Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors, Can. J. Chem. 2016, 94 , 240-250.
• 2015
  Labesse G, Alexandre T, Gelin M, Haouz A, Munier-Lehmann H, Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation, Acta Crystallogr. D Biol. Crystallogr. 2015 Sep;71(Pt 9):1890-9.
• 2015
  Lucas-Hourani M, Munier-Lehmann H, El Mazouni F, Malmquist NA, Harpon J, Coutant EP, Guillou S, Helynck O, Noel A, Scherf A, Phillips MA, Tangy F, Vidalain PO, Janin YL, Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH), J. Med. Chem. 2015 Jul;58(14):5579-98.
• 2015
  Munier-Lehmann H, Lucas-Hourani M, Guillou S, Helynck O, Zanghi G, Noel A, Tangy F, Vidalain PO, Janin YL, Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH), J. Med. Chem. 2015 Jan;58(2):860-77.
• 2014
  Lucas-Hourani M, Munier-Lehmann H, Helynck O, Komarova A, Desprès P, Tangy F, Vidalain PO, High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses, J Vis Exp 2014;(87).
• 2013
  Lucas-Hourani M, Dauzonne D, Jorda P, Cousin G, Lupan A, Helynck O, Caignard G, Janvier G, André-Leroux G, Khiar S, Escriou N, Desprès P, Jacob Y, Munier-Lehmann H, Tangy F, Vidalain PO, Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity, PLoS Pathog. 2013;9(10):e1003678.
• 2013
  Carré C, Jacquier C, Bougé AL, de Chaumont F, Besnard-Guerin C, Thomassin H, Pidoux J, Da Silva B, Chalatsi E, Zahra S, Olivo-Marin JC, Munier-Lehmann H, Antoniewski C, AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity, PLoS ONE 2013;8(9):e74296.
• 2013
  Munier-Lehmann H, Vidalain PO, Tangy F, Janin YL, On dihydroorotate dehydrogenases and their inhibitors and uses, J. Med. Chem. 2013 Apr;56(8):3148-67.
• 2013
  Zeidler U, Bougnoux ME, Lupan A, Helynck O, Doyen A, Garcia Z, Sertour N, Clavaud C, Munier-Lehmann H, Saveanu C, d'Enfert C, Synergy of the antibiotic colistin with echinocandin antifungals in Candida species, J. Antimicrob. Chemother. 2013 Jun;68(6):1285-96.
• 2012
  Toti KS, Verbeke F, Risseeuw MD, Frecer V, Munier-Lehmann H, Van Calenbergh S, Synthesis and evaluation of 5′-modified thymidines and 5-hydroxymethyl-2′-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors, Bioorg. Med. Chem. 2013 Jan;21(1):257-68.
• 2012
  Lucas-Hourani M, Lupan A, Desprès P, Thoret S, Pamlard O, Dubois J, Guillou C, Tangy F, Vidalain PO, Munier-Lehmann H, A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2, J Biomol Screen 2013 Feb;18(2):172-9.
• 2012
  Clavaud C, Beauvais A, Barbin L, Munier-Lehmann H, Latgé JP, The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis, Antimicrob. Agents Chemother. 2012 Jun;56(6):3428-31.
• 2012
  Kögler M, Busson R, De Jonghe S, Rozenski J, Van Belle K, Louat T, Munier-Lehmann H, Herdewijn P, Synthesis and evaluation of 6-aza-2′-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis, Chem. Biodivers. 2012 Mar;9(3):536-56.
• 2012
  Van Calenbergh S, Pochet S, Munier-Lehmann H, Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase, Curr Top Med Chem 2012;12(7):694-705.
• 2011
  Van Poecke S, Munier-Lehmann H, Helynck O, Froeyen M, Van Calenbergh S, Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase, Bioorg. Med. Chem. 2011 Dec;19(24):7603-11.
• 2010
  Labesse G, Benkali K, Salard-Arnaud I, Gilles AM, Munier-Lehmann H, Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation, Nucleic Acids Res. 2011 Apr;39(8):3458-72.
• 2010
  Familiar O, Munier-Lehmann H, Aínsa JA, Camarasa MJ, Pérez-Pérez MJ, Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone, Eur J Med Chem 2010 Dec;45(12):5910-8.
• 2009
  Auvynet C, Topalis D, Caillat C, Munier-Lehmann H, Seclaman E, Balzarini J, Agrofoglio LA, Kaminski PA, Meyer P, Deville-Bonne D, El Amri C, Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase, Biochem. Biophys. Res. Commun. 2009 Oct;388(1):6-11.
• 2008
  Binesse J, Delsert C, Saulnier D, Champomier-Vergès MC, Zagorec M, Munier-Lehmann H, Mazel D, Le Roux F, Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus, Appl. Environ. Microbiol. 2008 Dec;74(23):7108-17.
• 2008
  Familiar O, Munier-Lehmann H, Negri A, Gago F, Douguet D, Rigouts L, Hernández AI, Camarasa MJ, Pérez-Pérez MJ, Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, ChemMedChem 2008 Jul;3(7):1083-93.
• 2008
  Gasse C, Douguet D, Huteau V, Marchal G, Munier-Lehmann H, Pochet S, Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity, Bioorg. Med. Chem. 2008 Jun;16(11):6075-85.
• 2008
  Topalis D, Alvarez K, Barral K, Munier-Lehmann H, Schneider B, Véron M, Guerreiro C, Mulard L, El-Amri C, Canard B, Deville-Bonne D, Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position, Nucleosides Nucleotides Nucleic Acids 2008 Apr;27(4):319-31.
• 2007
  Van Daele I, Munier-Lehmann H, Froeyen M, Balzarini J, Van Calenbergh S, Rational design of 5′-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth, J. Med. Chem. 2007 Nov;50(22):5281-92.
• 2007
  Ofiteru A, Bucurenci N, Alexov E, Bertrand T, Briozzo P, Munier-Lehmann H, Gilles AM, Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase, FEBS J. 2007 Jul;274(13):3363-73.
• 2007
  Gasse C, Huteau V, Douguet D, Munier-Lehmann H, Pochet S, A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase, Nucleosides Nucleotides Nucleic Acids 2007;26(8-9):1057-61.
• 2006
  Van Daele I, Munier-Lehmann H, Hendrickx PM, Marchal G, Chavarot P, Froeyen M, Qing L, Martins JC, Van Calenbergh S, Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase, ChemMedChem 2006 Oct;1(10):1081-90.
• 2006
  Frachon E, Bondet V, Munier-Lehmann H, Bellalou J, Multiple microfermentor battery: a versatile tool for use with automated parallel cultures of microorganisms producing recombinant proteins and for optimization of cultivation protocols, Appl. Environ. Microbiol. 2006 Aug;72(8):5225-31.
• 2006
  Bellinzoni M, Haouz A, Graña M, Munier-Lehmann H, Shepard W, Alzari PM, , The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer., Protein Sci 2006 Jun; 15(6): 1489-93.
• 2006
  Hible G, Christova P, Renault L, Seclaman E, Thompson A, Girard E, Munier-Lehmann H, Cherfils J, Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase, Proteins 2006 Feb;62(2):489-500.
• 2005
  Douguet D, Munier-Lehmann H, Labesse G, Pochet S, LEA3D: a computer-aided ligand design for structure-based drug design, J. Med. Chem. 2005 Apr;48(7):2457-68.
• 2005
  Fioravanti E, Adam V, Munier-Lehmann H, Bourgeois D, The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3′-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition, Biochemistry 2005 Jan;44(1):130-7.
• 2004
  Vanheusden V, Munier-Lehmann H, Froeyen M, Busson R, Rozenski J, Herdewijn P, Van Calenbergh S, Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase, J. Med. Chem. 2004 Dec;47(25):6187-94.
• 2004
  León RG, Munier-Lehmann H, Barzu O, Baudin-Creuza V, Pietri R, López-Garriga J, Cadilla CL, High-level production of recombinant sulfide-reactive hemoglobin I from Lucina pectinata in Escherichia coli. High yields of fully functional holoprotein synthesis in the BLi5 E. coli strain, Protein Expr. Purif. 2004 Dec;38(2):184-95.
• 2004
  Gallay J, Vincent M, Li de la Sierra IM, Munier-Lehmann H, Renouard M, Sakamoto H, Bârzu O, Gilles AM, Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy, Eur. J. Biochem. 2004 Feb;271(4):821-33.
• 2004
  Miron S, Munier-Lehmann H, Craescu CT, Structural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity, Biochemistry 2004 Jan;43(1):67-77.
• 2003
  Vanheusden V, Van Rompaey P, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S, Thymidine and thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, Bioorg. Med. Chem. Lett. 2003 Sep;13(18):3045-8.
• 2003
  Vanheusden V, Munier-Lehmann H, Froeyen M, Dugué L, Heyerick A, De Keukeleire D, Pochet S, Busson R, Herdewijn P, Van Calenbergh S, 3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase, J. Med. Chem. 2003 Aug;46(18):3811-21.
• 2003
  Pochet S, Dugué L, Labesse G, Delepierre M, Munier-Lehmann H, Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans, Chembiochem 2003 Aug;4(8):742-7.
• 2003
  Van Rompaey, P., Nauwelaerts, K., Vanheusden, V., Rozenski, J., Munier-Lehmann, H., Herdewijn, P. and Van Calenbergh, S., Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors: Biological evaluation and conformational analysis of 2 ‘- and 3 ‘-modified thymidine analogues, Eur. J. Org. Chem., 2003: 2911–2918. doi: 10.1002/ejoc.200300177.
• 2003
  Munier-Lehmann H, Chenal-Francisque V, Ionescu M, Chrisova P, Foulon J, Carniel E, Bârzu O, Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent, Biochem. J. 2003 Jul;373(Pt 2):515-22.
• 2003
  Munier-Lehmann H, Pochet S, Dugue L, Dutruel O, Labesse G, Douget D, Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors, Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):801-4.
• 2003
  Fioravanti E, Haouz A, Ursby T, Munier-Lehmann H, Delarue M, Bourgeois D, Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway, J. Mol. Biol. 2003 Apr;327(5):1077-92.
• 2003
  Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D, Reaction of human UMP-CMP kinase with natural and analog substrates, Eur. J. Biochem. 2003 Apr;270(8):1784-90.
• 2003
  Haouz A, Vanheusden V, Munier-Lehmann H, Froeyen M, Herdewijn P, Van Calenbergh S, Delarue M, Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism, J. Biol. Chem. 2003 Feb;278(7):4963-71.
• 2002
  Vanheusden V, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S, Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, Bioorg. Med. Chem. Lett. 2002 Oct;12(19):2695-8.
• 2002
  Manallack DT, Pitt WR, Herdewijn P, Balzarini J, De Clercq E, Sanderson MR, Sohi M, Wien F, Munier-Lehmann H, Haouz A, Delarue M, Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods, J Enzyme Inhib Med Chem 2002 Jun;17(3):167-74.
• 2002
  Bertrand T, Briozzo P, Assairi L, Ofiteru A, Bucurenci N, Munier-Lehmann H, Golinelli-Pimpaneau B, Bârzu O, Gilles AM, Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme, J. Mol. Biol. 2002 Feb;315(5):1099-110.
• 2002
  Pochet S, Dugue L, Douguet D, Labesse G, Munier-Lehmann H, Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications, Chembiochem 2002 Jan;3(1):108-10.
• 2001
  Li de la Sierra I, Munier-Lehmann H, Gilles AM, Bârzu O, Delarue M, X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution, J. Mol. Biol. 2001 Aug;311(1):87-100.
• 2001
  Munier-Lehmann H, Chaffotte A, Pochet S, Labesse G, Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes, Protein Sci. 2001 Jun;10(6):1195-205.
• 2001
  Miron S, Munier-Lehmann H, Craescu CT, 1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase, J. Biomol. NMR 2001 Jan;19(1):89-90.
• 2000
  Li de la Sierra I, Munier-Lehmann H, Gilles AM, Bârzu O, Delarue M, Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis, Acta Crystallogr. D Biol. Crystallogr. 2000 Feb;56(Pt 2):226-8.
• 1999
  Munier-Lehmann H, Burlacu-Miron S, Craescu CT, Mantsch HH, Schultz CP, A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: A predictive and experimental study, Proteins 1999 Aug;36(2):238-48.
• 1996
  Munier-Lehmann H, Mauxion F, Bauer U, Lobel P, Hoflack B, , Re-expression of the mannose 6-phosphate receptors in receptor-deficient fibroblasts. Complementary function of the two mannose 6-phosphate receptors in lysosomal enzyme targeting., J Biol Chem 1996 Jun; 271(25): 15166-74.
• 1996
  Mauxion F, Le Borgne R, Munier-Lehmann H, Hoflack B, , A casein kinase II phosphorylation site in the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor determines the high affinity interaction of the AP-1 Golgi assembly proteins with membranes., J Biol Chem 1996 Jan; 271(4): 2171-8.
• 1994
  Ludwig T, Munier-Lehmann H, Bauer U, Hollinshead M, Ovitt C, Lobel P, Hoflack B, , Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts., EMBO J 1994 Aug; 13(15): 3430-7.
• 1993
  Gilles AM, Sismeiro O, Munier H, Fabian H, Mantsch HH, Surewicz WK, Craescu CC, Barzu O, Danchin A, , Structural and physico-chemical characteristics of Bordetella pertussis adenylate kinase, a tryptophan-containing enzyme., Eur J Biochem 1993 Dec; 218(3): 921-7.
• 1993
  Munier H, Bouhss A, Gilles AM, Krin E, Glaser P, Danchin A, Bârzu O, , Structural flexibility of the calmodulin-binding locus in Bordetella pertussis adenylate cyclase. Reconstitution of catalytically active species from fragments or inactive forms of the enzyme., Eur J Biochem 1993 Oct; 217(2): 581-6.
• 1993
  Munier H, Blanco FJ, Prêcheur B, Diesis E, Nieto JL, Craescu CT, Bârzu O, , Characterization of a synthetic calmodulin-binding peptide derived from Bacillus anthracis adenylate cyclase., J Biol Chem 1993 Jan; 268(3): 1695-701.
• 1993
  Bouhss A, Krin E, Munier H, Gilles AM, Danchin A, Glaser P, Bârzu O, , Cooperative phenomena in binding and activation of Bordetella pertussis adenylate cyclase by calmodulin., J Biol Chem 1993 Jan; 268(3): 1690-4.
• 1992
  Munier H, Bouhss A, Krin E, Danchin A, Gilles AM, Glaser P, Bârzu O, , The role of histidine 63 in the catalytic mechanism of Bordetella pertussis adenylate cyclase., J Biol Chem 1992 May; 267(14): 9816-20.
• 1992
  Prêcheur B, Munier H, Mispelter J, Bârzu O, Craescu CT, , 1H and 15N NMR characterization of free and bound states of an amphiphilic peptide interacting with calmodulin., Biochemistry 1992 Jan; 31(1): 229-36.
• 1991
  Glaser P, Munier H, Gilles AM, Krin E, Porumb T, Bârzu O, Sarfati R, Pellecuer C, Danchin A, , Functional consequences of single amino acid substitutions in calmodulin-activated adenylate cyclase of Bordetella pertussis., EMBO J 1991 Jul; 10(7): 1683-8.
• 1991
  Munier H, Gilles AM, Glaser P, Krin E, Danchin A, Sarfati R, Bârzu O, , Isolation and characterization of catalytic and calmodulin-binding domains of Bordetella pertussis adenylate cyclase., Eur J Biochem 1991 Mar; 196(2): 469-74.
• 1990
  Gilles AM, Munier H, Rose T, Glaser P, Krin E, Danchin A, Pellecuer C, Bârzu O, , Intrinsic fluorescence of a truncated Bordetella pertussis adenylate cyclase expressed in Escherichia coli., Biochemistry 1990 Sep; 29(35): 8126-30.