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  • 2025
    Puszko AK, Batista FA, Ejjoummany A, Bouillon A, Maurel M, Adler P, Legru A, Martinez M, Ortega Varga L, Hadjadj M, Alzari PM, Blondel A, Haouz A, Barale JC, Hernandez JF, Towards Improved Peptidic α-Ketoamide Inhibitors of the Plasmodial Subtilisin-Like SUB1: Exploration of N-Terminal Extensions and Cyclic Constraints., ChemMedChem 2025 Jan; (): e202400924.
  • 2024
    Legru A, Batista FA, Puszko AK, Bouillon A, Maurel M, Martinez M, Ejjoummany A, Ortega Varga L, Adler P, Méchaly A, Hadjadj M, Sosnowski P, Hopfgartner G, Alzari PM, Blondel A, Haouz A, Barale JC, Hernandez JF, Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1., Eur J Med Chem 2024 Apr; 269(): 116308.
  • 2024
    Martinez M, Bouillon A, Brûlé S, Raynal B, Haouz A, Alzari PM, Barale J-C, Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress., mBio 2024 Mar; 15(3): e0019824.
  • 2022
    Mairet-Khedim M, Roesch C, Khim N, Srun S, Bouillon A, Kim S, Ke S, Kauy C, Kloeung N, Eam R, Khean C, Kul C, Chy S, Leang R, Ringwald P, Barale JC, Witkowski B, Prevalence and characterization of piperaquine, mefloquine and artemisinin derivatives triple-resistant Plasmodium falciparum in Cambodia., J Antimicrob Chemother 2022 Dec; (): .
  • 2022
    Wagner MP, Formaglio P, Gorgette O, Dziekan JM, Huon C, Berneburg I, Rahlfs S, Barale JC, Feinstein SI, Fisher AB, Ménard D, Bozdech Z, Amino R, Touqui L, Chitnis CE, , Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target., Cell Rep 2022 Jun; 39(11): 110923.
  • 2014
    Bastianelli G, Bouillon A, Nguyen C, Le-Nguyen D, Nilges M, Barale JC, Computational design of protein-based inhibitors of Plasmodium vivax subtilisin-like 1 protease, PLoS ONE 2014;9(10):e109269.
  • 2014
    Moine E, Denevault-Sabourin C, Debierre-Grockiego F, Silpa L, Gorgette O, Barale JC, Jacquiet P, Brossier F, Gueiffier A, Dimier-Poisson I, Enguehard-Gueiffier C, A small-molecule cell-based screen led to the identification of biphenylimidazoazines with highly potent and broad-spectrum anti-apicomplexan activity, Eur J Med Chem 2015 Jan;89:386-400.
  • 2014
    Giganti D, Bouillon A, Tawk L, Robert F, Martinez M, Crublet E, Weber P, Girard-Blanc C, Petres S, Haouz A, Hernandez JF, Mercereau-Puijalon O, Alzari PM, Barale JC, A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase, Nat Commun 2014 Sep;5:4833.
  • 2014
    Varela ML, Razakandrainibe R, Aldebert D, Barale JC, Jambou R, Cytometric measurement of in vitro inhibition of Plasmodium falciparum field isolates by drugs: a new approach for re-invasion inhibition study, Malar. J. 2014;13:110.
  • 2014
    Jacob D, Ruffie C, Dubois M, Combredet C, Amino R, Formaglio P, Gorgette O, Pehau-Arnaudet G, Guery C, Puijalon O, Barale JC, Ménard R, Tangy F, Sala M, Whole Pichia pastoris yeast expressing measles virus nucleoprotein as a production and delivery system to multimerize Plasmodium antigens., PLoS One 2014 ; 9(1): e86658.
  • 2013
    Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, Kim S, Duru V, Bouchier C, Ma L, Lim P, Leang R, Duong S, Sreng S, Suon S, Chuor CM, Bout DM, Ménard S, Rogers WO, Genton B, Fandeur T, Miotto O, Ringwald P, Le Bras J, Berry A, Barale JC, Fairhurst RM, Benoit-Vical F, Mercereau-Puijalon O, Ménard D, A molecular marker of artemisinin-resistant Plasmodium falciparum malaria, Nature 2014 Jan;505(7481):50-5.
  • 2013
    Bouillon A, Giganti D, Benedet C, Gorgette O, Pêtres S, Crublet E, Girard-Blanc C, Witkowski B, Ménard D, Nilges M, Mercereau-Puijalon O, Stoven V, Barale JC, In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound, J. Biol. Chem. 2013 Jun;288(25):18561-73.
  • 2013
    Bouillon A, Gorgette O, Mercereau-Puijalon O, Barale JC, Screening and evaluation of inhibitors of Plasmodium falciparum merozoite egress and invasion using cytometry, Methods Mol. Biol. 2013;923:523-34.
  • 2012
    Witkowski B, Khim N, Chim P, Kim S, Ke S, Kloeung N, Chy S, Duong S, Leang R, Ringwald P, Dondorp AM, Tripura R, Benoit-Vical F, Berry A, Gorgette O, Ariey F, Barale JC, Mercereau-Puijalon O, Menard D, Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia, Antimicrob. Agents Chemother. 2013 Feb;57(2):914-23.
  • 2011
    Lacroix C, Giovannini D, Combe A, Bargieri DY, Späth S, Panchal D, Tawk L, Thiberge S, Carvalho TG, Barale JC, Bhanot P, Ménard R, FLP/FRT-mediated conditional mutagenesis in pre-erythrocytic stages of Plasmodium berghei, Nat Protoc 2011 Sep;6(9):1412-28.
  • 2011
    Bastianelli G, Bouillon A, Nguyen C, Crublet E, Pêtres S, Gorgette O, Le-Nguyen D, Barale JC, Nilges M, Computational reverse-engineering of a spider-venom derived peptide active against Plasmodium falciparum SUB1, PLoS ONE 2011;6(7):e21812.
  • 2011
    Wlodarczyk, N.; Simenel, C.; Delepierre, M.; Barale, J. C.; Janin, Y. L., On the Knorr synthesis of 6-bromo-4-methylquinolin-2(1H)-one, Synthesis 2011, (6), 934-942.
  • 2010
    Barale JC, Ménard R, Centromeric plasmids and artificial chromosomes: new kids on the Plasmodium transfection block, Cell Host Microbe 2010 Mar;7(3):181-3.
  • 2009
    Bougdour A, Maubon D, Baldacci P, Ortet P, Bastien O, Bouillon A, Barale JC, Pelloux H, Ménard R, Hakimi MA, Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites, J. Exp. Med. 2009 Apr;206(4):953-66.
  • 2005
    Chamond N, Goytia M, Coatnoan N, Barale JC, Cosson A, Degrave WM, Minoprio P, Trypanosoma cruzi proline racemases are involved in parasite differentiation and infectivity, Mol. Microbiol. 2005 Oct;58(1):46-60.
  • 2005
    Blisnick T, Vincensini L, Barale JC, Namane A, Braun Breton C, LANCL1, an erythrocyte protein recruited to the Maurer’s clefts during Plasmodium falciparum development, Mol. Biochem. Parasitol. 2005 May;141(1):39-47.
  • 2005
    Boeuf P, Vigan-Womas I, Jublot D, Loizon S, Barale JC, Akanmori BD, Mercereau-Puijalon O, Behr C, CyProQuant-PCR: a real time RT-PCR technique for profiling human cytokines, based on external RNA standards, readily automatable for clinical use, BMC Immunol. 2005;6:5.
  • 2004
    Uzureau P, Barale JC, Janse CJ, Waters AP, Breton CB, Gene targeting demonstrates that the Plasmodium berghei subtilisin PbSUB2 is essential for red cell invasion and reveals spontaneous genetic recombination events, Cell. Microbiol. 2004 Jan;6(1):65-78.
  • 2002
    Mercereau-Puijalon O, Barale JC, Bischoff E, Three multigene families in Plasmodium parasites: facts and questions, Int. J. Parasitol. 2002 Oct;32(11):1323-44.
  • 2000
    Blisnick T, Morales Betoulle ME, Barale JC, Uzureau P, Berry L, Desroses S, Fujioka H, Mattei D, Braun Breton C, Pfsbp1, a Maurer’s cleft Plasmodium falciparum protein, is associated with the erythrocyte skeleton, Mol. Biochem. Parasitol. 2000 Nov;111(1):107-21.
  • 1999
    Barale JC, Blisnick T, Fujioka H, Alzari PM, Aikawa M, Braun-Breton C, Langsley G, Plasmodium falciparum subtilisin-like protease 2, a merozoite candidate for the merozoite surface protein 1-42 maturase, Proc. Natl. Acad. Sci. U.S.A. 1999 May;96(11):6445-50.
  • 1999
    Seidah NG, Mowla SJ, Hamelin J, Mamarbachi AM, Benjannet S, Touré BB, Basak A, Munzer JS, Marcinkiewicz J, Zhong M, Barale JC, Lazure C, Murphy RA, Chrétien M, Marcinkiewicz M, Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization, Proc. Natl. Acad. Sci. U.S.A. 1999 Feb;96(4):1321-6.
  • 1998
    Girardin SE, Benjannet S, Barale JC, Chrétien M, Seidah NG, The LIM homeobox protein mLIM3/Lhx3 induces expression of the prolactin gene by a Pit-1/GHF-1-independent pathway in corticotroph AtT20 cells, FEBS Lett. 1998 Jul;431(3):333-8.
  • 1997
    Barale JC, Candelle D, Attal-Bonnefoy G, Dehoux P, Bonnefoy S, Ridley R, Pereira da Silva L, Langsley G, Plasmodium falciparum AARP1, a giant protein containing repeated motifs rich in asparagine and aspartate residues, is associated with the infected erythrocyte membrane, Infect. Immun. 1997 Aug;65(8):3003-10.
  • 1997
    Barale JC, Attal-Bonnefoy G, Brahimi K, Pereira da Silva L, Langsley G, Plasmodium falciparum asparagine and aspartate rich protein 2 is an evolutionary conserved protein whose repeats identify a new family of parasite antigens, Mol. Biochem. Parasitol. 1997 Aug;87(2):169-81.
  • 1994
    Seidah NG, Barale JC, Marcinkiewicz M, Mattei MG, Day R, Chrétien M, The mouse homeoprotein mLIM-3 is expressed early in cells derived from the neuroepithelium and persists in adult pituitary, DNA Cell Biol. 1994 Dec;13(12):1163-80.
  • 1994
    Braun-Breton C, Blisnick T, Morales-Betoulle ME, Barale JC, Langsley G, Malaria parasites: enzymes involved in red blood cell invasion, Braz. J. Med. Biol. Res. 1994 Feb;27(2):363-7.
  • 1993
    Langsley G, Barale JC, Mattei D, Isolation from a Plasmodium chabaudi chromosome 7 specific library of a novel gene encoding a protein with multiple GGMP repeats homologous to hsp70, Mol. Biochem. Parasitol. 1993 Jun;59(2):331-4.
  • 1992
    Breton CB, Blisnick T, Jouin H, Barale JC, Rabilloud T, Langsley G, Pereira da Silva LH, Plasmodium chabaudi p68 serine protease activity required for merozoite entry into mouse erythrocytes, Proc. Natl. Acad. Sci. U.S.A. 1992 Oct;89(20):9647-51.
  • 1992
    Langsley G, Kaslow DC, Barbot P, Blisnick T, Ponnudurai T, Barale JC, Braun-Breton C, A Plasmodium falciparum gene coding for a 15-kilodalton antigen expressed in asexual stage parasites, gametocytes and gametes, Mol. Biochem. Parasitol. 1992 Oct;55(1-2):221-4.
  • 1991
    Giesecke H, Barale JC, Langsley G, Cornelissen AW, The C-terminal domain of RNA polymerase II of the malaria parasite Plasmodium berghei, Biochem. Biophys. Res. Commun. 1991 Nov;180(3):1350-5.
  • 1991
    Barale JC, Langsley G, Mangel WF, Braun-Breton C, Malarial proteases: assignment of function to activity, Res. Immunol. 1991 Oct;142(8):672-81.
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