• 2019
  Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugué L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H, First-in-class allosteric inhibitors of bacterial IMPDHs, Eur J Med Chem 2019 Feb;167:124-132.
• 2018
  Thieulent CJ, Hue ES, Fortier CI, Dallemagne P, Zientara S, Munier-Lehmann H, Hans A, Fortier GD, Pitel PH, Vidalain PO, Pronost SL, Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay, Virology 2019 01;526:105-116.
• 2018
  Laskaris P, Vicentefranqueira R, Helynck O, Jouvion G, Calera JA, du Merle L, Suzenet F, Buron F, de Sousa RA, Mansuy D, Cavaillon JM, Latgé JP, Munier-Lehmann H, Ibrahim-Granet O, A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism, Antimicrob. Agents Chemother. 2018 Jun;62(6).
• 2018
  Harigua-Souiai E, Abdelkrim YZ, Bassoumi-Jamoussi I, Zakraoui O, Bouvier G, Essafi-Benkhadir K, Banroques J, Desdouits N, Munier-Lehmann H, Barhoumi M, Tanner NK, Nilges M, Blondel A, Guizani I, Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A, PLoS Negl Trop Dis 2018 01;12(1):e0006160.
• 2018
  Suthagar K, Jiao W, Munier-Lehmann H, Fairbanks AJ, Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis, Carbohydr. Res. 2018 Mar;457:32-40.
• 2017
  Dabo S., Maillard P., Collados Rodriguez M., Hansen M. D., Mazouz S., Bigot D. J., Tible M., Janvier G., Helynck O., Cassonnet P., Jacob Y., Bellalou J., Gatignol A., Patel R. C., Hugon J., Munier-Lehmann H., Meurs E. F., Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT, Sci Rep. 2017 Nov 23;7(1):16129.
• 2017
  Buchieri MV, Cimino M, Rebollo-Ramirez S, Beauvineau C, Cascioferro A, Favre-Rochex S, Helynck O, Naud-Martin D, Larrouy-Maumus G, Munier-Lehmann H, Gicquel B, Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis, J. Med. Chem. 2017 Sep 14;60(17):7425-7433.
• 2017
  Lucas-Hourani M, Dauzonne D, Munier-Lehmann H, Khiar S, Nisole S, Dairou J, Helynck O, Afonso PV, Tangy F, Vidalain PO, Original chemical series of pyrimidine biosynthesis inhibitors that boost the antiviral interferon response, Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00383-17.
• 2017
  Khiar S, Lucas-Hourani M, Nisole S, Smith N, Helynck O, Bourgine M, Ruffié C, Herbeuval JP, Munier-Lehmann H, Tangy F, Vidalain PO, Identification of a small molecule that primes the type I interferon response to cytosolic DNA, Sci Rep 2017 05;7(1):2561.
• 2016
  Laskaris P, Atrouni A, Calera JA, d'Enfert C, Munier-Lehmann H, Cavaillon JM, Latgé JP, Ibrahim-Granet O, Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin, Antimicrob. Agents Chemother. 2016 Oct;60(10):5631-9.
• 2016
  Song L, Risseeuw MDP, Froeyen M, Karalic I, Goeman J, Cappoen D, Van der Eycken J, Cos P, Munier-Lehmann H, Van Calenbergh S, Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents, Bioorg. Med. Chem. 2016 11;24(21):5172-5182.
• 2016
  Adamska A, Rumijowska-Galewicz A, Ruszczynska A, Studzińska M, Jabłońska A, Paradowska E, Bulska E, Munier-Lehmann H, Dziadek J, Leśnikowski ZJ, Olejniczak AB, Anti-mycobacterial activity of thymine derivatives bearing boron clusters, Eur J Med Chem 2016 Oct;121:71-81.
• 2016
  Grandin C, Hourani ML, Janin YL, Dauzonne D, Munier-Lehmann H, Paturet A, Taborik F, Vabret A, Contamin H, Tangy F, Vidalain PO, Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors, Antiviral Res. 2016 Jan;125:58-62.
• 2015
  Raj S, Krishnan K, Askew DS, Helynck O, Suzanne P, Lesnard A, Rault S, Zeidler U, d'Enfert C, Latgé JP, Munier-Lehmann H, Saveanu C, The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components, Antimicrob. Agents Chemother. 2015;60(3):1438-49.
• 2015
  Labesse G, Alexandre T, Gelin M, Haouz A, Munier-Lehmann H, Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation, Acta Crystallogr. D Biol. Crystallogr. 2015 Sep;71(Pt 9):1890-9.
• 2015
  Lucas-Hourani M, Munier-Lehmann H, El Mazouni F, Malmquist NA, Harpon J, Coutant EP, Guillou S, Helynck O, Noel A, Scherf A, Phillips MA, Tangy F, Vidalain PO, Janin YL, Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH), J. Med. Chem. 2015 Jul;58(14):5579-98.
• 2015
  Alexandre T, Raynal B, Rayna B, Munier-Lehmann H, Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties, PLoS ONE 2015;10(2):e0116578.
• 2015
  Vidalain PO, Lucas-Hourani M, Helynck O, Tangy F, Munier-Lehmann H, [Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening], Med Sci (Paris) 2015 Jan;31(1):98-104.
• 2015
  Munier-Lehmann H, Lucas-Hourani M, Guillou S, Helynck O, Zanghi G, Noel A, Tangy F, Vidalain PO, Janin YL, Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH), J. Med. Chem. 2015 Jan;58(2):860-77.
• 2014
  Lucas-Hourani M, Munier-Lehmann H, Helynck O, Komarova A, Desprès P, Tangy F, Vidalain PO, High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses, J Vis Exp 2014;(87).
• 2013
  Lucas-Hourani M, Dauzonne D, Jorda P, Cousin G, Lupan A, Helynck O, Caignard G, Janvier G, André-Leroux G, Khiar S, Escriou N, Desprès P, Jacob Y, Munier-Lehmann H, Tangy F, Vidalain PO, Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity, PLoS Pathog. 2013;9(10):e1003678.
• 2013
  Carré C, Jacquier C, Bougé AL, de Chaumont F, Besnard-Guerin C, Thomassin H, Pidoux J, Da Silva B, Chalatsi E, Zahra S, Olivo-Marin JC, Munier-Lehmann H, Antoniewski C, AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity, PLoS ONE 2013;8(9):e74296.
• 2013
  Labesse G, Alexandre T, Vaupré L, Salard-Arnaud I, Him JL, Raynal B, Bron P, Munier-Lehmann H, MgATP regulates allostery and fiber formation in IMPDHs, Structure 2013 Jun;21(6):975-85.
• 2013
  Aulner N, Danckaert A, Rouault-Hardoin E, Desrivot J, Helynck O, Commere PH, Munier-Lehmann H, Späth GF, Shorte SL, Milon G, Prina E, High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery, PLoS Negl Trop Dis 2013;7(4):e2154.
• 2013
  Munier-Lehmann H, Vidalain PO, Tangy F, Janin YL, On dihydroorotate dehydrogenases and their inhibitors and uses, J. Med. Chem. 2013 Apr;56(8):3148-67.
• 2013
  Zeidler U, Bougnoux ME, Lupan A, Helynck O, Doyen A, Garcia Z, Sertour N, Clavaud C, Munier-Lehmann H, Saveanu C, d'Enfert C, Synergy of the antibiotic colistin with echinocandin antifungals in Candida species, J. Antimicrob. Chemother. 2013 Jun;68(6):1285-96.
• 2012
  Toti KS, Verbeke F, Risseeuw MD, Frecer V, Munier-Lehmann H, Van Calenbergh S, Synthesis and evaluation of 5′-modified thymidines and 5-hydroxymethyl-2′-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors, Bioorg. Med. Chem. 2013 Jan;21(1):257-68.
• 2012
  Lucas-Hourani M, Lupan A, Desprès P, Thoret S, Pamlard O, Dubois J, Guillou C, Tangy F, Vidalain PO, Munier-Lehmann H, A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2, J Biomol Screen 2013 Feb;18(2):172-9.
• 2012
  Clavaud C, Beauvais A, Barbin L, Munier-Lehmann H, Latgé JP, The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis, Antimicrob. Agents Chemother. 2012 Jun;56(6):3428-31.
• 2012
  Kögler M, Busson R, De Jonghe S, Rozenski J, Van Belle K, Louat T, Munier-Lehmann H, Herdewijn P, Synthesis and evaluation of 6-aza-2′-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis, Chem. Biodivers. 2012 Mar;9(3):536-56.
• 2012
  Van Calenbergh S, Pochet S, Munier-Lehmann H, Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase, Curr Top Med Chem 2012;12(7):694-705.
• 2011
  Van Poecke S, Munier-Lehmann H, Helynck O, Froeyen M, Van Calenbergh S, Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase, Bioorg. Med. Chem. 2011 Dec;19(24):7603-11.
• 2010
  Labesse G, Benkali K, Salard-Arnaud I, Gilles AM, Munier-Lehmann H, Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation, Nucleic Acids Res. 2011 Apr;39(8):3458-72.
• 2010
  Familiar O, Munier-Lehmann H, Aínsa JA, Camarasa MJ, Pérez-Pérez MJ, Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone, Eur J Med Chem 2010 Dec;45(12):5910-8.
• 2009
  Auvynet C, Topalis D, Caillat C, Munier-Lehmann H, Seclaman E, Balzarini J, Agrofoglio LA, Kaminski PA, Meyer P, Deville-Bonne D, El Amri C, Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase, Biochem. Biophys. Res. Commun. 2009 Oct;388(1):6-11.
• 2008
  Binesse J, Delsert C, Saulnier D, Champomier-Vergès MC, Zagorec M, Munier-Lehmann H, Mazel D, Le Roux F, Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus, Appl. Environ. Microbiol. 2008 Dec;74(23):7108-17.
• 2008
  Familiar O, Munier-Lehmann H, Negri A, Gago F, Douguet D, Rigouts L, Hernández AI, Camarasa MJ, Pérez-Pérez MJ, Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, ChemMedChem 2008 Jul;3(7):1083-93.
• 2008
  Gasse C, Douguet D, Huteau V, Marchal G, Munier-Lehmann H, Pochet S, Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity, Bioorg. Med. Chem. 2008 Jun;16(11):6075-85.
• 2008
  Topalis D, Alvarez K, Barral K, Munier-Lehmann H, Schneider B, Véron M, Guerreiro C, Mulard L, El-Amri C, Canard B, Deville-Bonne D, Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position, Nucleosides Nucleotides Nucleic Acids 2008 Apr;27(4):319-31.
• 2007
  Van Daele I, Munier-Lehmann H, Froeyen M, Balzarini J, Van Calenbergh S, Rational design of 5′-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth, J. Med. Chem. 2007 Nov;50(22):5281-92.
• 2007
  Ofiteru A, Bucurenci N, Alexov E, Bertrand T, Briozzo P, Munier-Lehmann H, Gilles AM, Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase, FEBS J. 2007 Jul;274(13):3363-73.
• 2007
  Gasse C, Huteau V, Douguet D, Munier-Lehmann H, Pochet S, A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase, Nucleosides Nucleotides Nucleic Acids 2007;26(8-9):1057-61.
• 2006
  Van Daele I, Munier-Lehmann H, Hendrickx PM, Marchal G, Chavarot P, Froeyen M, Qing L, Martins JC, Van Calenbergh S, Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase, ChemMedChem 2006 Oct;1(10):1081-90.
• 2006
  Frachon E, Bondet V, Munier-Lehmann H, Bellalou J, Multiple microfermentor battery: a versatile tool for use with automated parallel cultures of microorganisms producing recombinant proteins and for optimization of cultivation protocols, Appl. Environ. Microbiol. 2006 Aug;72(8):5225-31.
• 2006
  Bellinzoni M, Haouz A, Graña M, Munier-Lehmann H, Shepard W, Alzari PM, The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer, Protein Sci. 2006 Jun;15(6):1489-93.
• 2006
  Hible G, Christova P, Renault L, Seclaman E, Thompson A, Girard E, Munier-Lehmann H, Cherfils J, Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase, Proteins 2006 Feb;62(2):489-500.
• 2005
  Douguet D, Munier-Lehmann H, Labesse G, Pochet S, LEA3D: a computer-aided ligand design for structure-based drug design, J. Med. Chem. 2005 Apr;48(7):2457-68.
• 2005
  Fioravanti E, Adam V, Munier-Lehmann H, Bourgeois D, The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3′-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition, Biochemistry 2005 Jan;44(1):130-7.
• 2004
  Vanheusden V, Munier-Lehmann H, Froeyen M, Busson R, Rozenski J, Herdewijn P, Van Calenbergh S, Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase, J. Med. Chem. 2004 Dec;47(25):6187-94.
• 2004
  León RG, Munier-Lehmann H, Barzu O, Baudin-Creuza V, Pietri R, López-Garriga J, Cadilla CL, High-level production of recombinant sulfide-reactive hemoglobin I from Lucina pectinata in Escherichia coli. High yields of fully functional holoprotein synthesis in the BLi5 E. coli strain, Protein Expr. Purif. 2004 Dec;38(2):184-95.
• 2004
  Gallay J, Vincent M, Li de la Sierra IM, Munier-Lehmann H, Renouard M, Sakamoto H, Bârzu O, Gilles AM, Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy, Eur. J. Biochem. 2004 Feb;271(4):821-33.
• 2004
  Miron S, Munier-Lehmann H, Craescu CT, Structural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity, Biochemistry 2004 Jan;43(1):67-77.
• 2003
  Vanheusden V, Van Rompaey P, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S, Thymidine and thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, Bioorg. Med. Chem. Lett. 2003 Sep;13(18):3045-8.
• 2003
  Vanheusden V, Munier-Lehmann H, Froeyen M, Dugué L, Heyerick A, De Keukeleire D, Pochet S, Busson R, Herdewijn P, Van Calenbergh S, 3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase, J. Med. Chem. 2003 Aug;46(18):3811-21.
• 2003
  Pochet S, Dugué L, Labesse G, Delepierre M, Munier-Lehmann H, Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans, Chembiochem 2003 Aug;4(8):742-7.
• 2003
  Van Rompaey, P., Nauwelaerts, K., Vanheusden, V., Rozenski, J., Munier-Lehmann, H., Herdewijn, P. and Van Calenbergh, S., Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors: Biological evaluation and conformational analysis of 2 ‘- and 3 ‘-modified thymidine analogues, Eur. J. Org. Chem., 2003: 2911–2918. doi: 10.1002/ejoc.200300177.
• 2003
  Munier-Lehmann H, Chenal-Francisque V, Ionescu M, Chrisova P, Foulon J, Carniel E, Bârzu O, Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent, Biochem. J. 2003 Jul;373(Pt 2):515-22.
• 2003
  Munier-Lehmann H, Pochet S, Dugue L, Dutruel O, Labesse G, Douget D, Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors, Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):801-4.
• 2003
  Fioravanti E, Haouz A, Ursby T, Munier-Lehmann H, Delarue M, Bourgeois D, Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway, J. Mol. Biol. 2003 Apr;327(5):1077-92.
• 2003
  Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D, Reaction of human UMP-CMP kinase with natural and analog substrates, Eur. J. Biochem. 2003 Apr;270(8):1784-90.
• 2002
  Vanheusden V, Munier-Lehmann H, Pochet S, Herdewijn P, Van Calenbergh S, Synthesis and evaluation of thymidine-5′-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase, Bioorg. Med. Chem. Lett. 2002 Oct;12(19):2695-8.
• 2002
  Bertrand T, Briozzo P, Assairi L, Ofiteru A, Bucurenci N, Munier-Lehmann H, Golinelli-Pimpaneau B, Bârzu O, Gilles AM, Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme, J. Mol. Biol. 2002 Feb;315(5):1099-110.
• 2002
  Pochet S, Dugue L, Douguet D, Labesse G, Munier-Lehmann H, Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications, Chembiochem 2002 Jan;3(1):108-10.
• 2001
  Li de la Sierra I, Munier-Lehmann H, Gilles AM, Bârzu O, Delarue M, X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution, J. Mol. Biol. 2001 Aug;311(1):87-100.
• 2001
  Munier-Lehmann H, Chaffotte A, Pochet S, Labesse G, Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes, Protein Sci. 2001 Jun;10(6):1195-205.
• 2001
  Miron S, Munier-Lehmann H, Craescu CT, 1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase, J. Biomol. NMR 2001 Jan;19(1):89-90.
• 2000
  Li de la Sierra I, Munier-Lehmann H, Gilles AM, Bârzu O, Delarue M, Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis, Acta Crystallogr. D Biol. Crystallogr. 2000 Feb;56(Pt 2):226-8.
• 1999
  Munier-Lehmann H, Burlacu-Miron S, Craescu CT, Mantsch HH, Schultz CP, A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: A predictive and experimental study, Proteins 1999 Aug;36(2):238-48.