• 2025
  Najate Benamer, Hélène Le Ribeuz, Chloé Felgerolle, Charlotte Calvet, Olivier Postal, Baptiste Plion, Mauricio Saenz-Roldan, Marie Giorgi, Marie-José Lecomte, Yann Nguyen, Christine Petit, Nicolas Michalski, Boris Gourévitch, Omar Akil, Saaid Safieddine, Cochlear gene therapy restores hearing and auditory processing in an atypical DFNB9 mouse model, Communications Medicine, 2025, 5 (1), pp.229. ⟨10.1038/s43856-025-00926-3⟩.
• 2025
  Iranfar S, Cornille M, Roldan MS, Plion B, Lecomte MJ, Safieddine S, Lahlou G, Cell tropism of adeno-associated viruses within the mouse inner ear in vivo: from embryonic to adult stages., Sci Rep 2025 Apr; 15(1): 13479.
• 2025
  Underhill A, Webb S, Grandi FC, Jeng JY, de Monvel JB, Plion B, Carlton AJ, Amariutei AE, Voulgari N, De Faveri F, Ceriani F, Mustapha M, Johnson SL, Safieddine S, Kros CJ, Marcotti W, MYO7A is required for the functional integrity of the mechanoelectrical transduction complex in hair cells of the adult cochlea., Proc Natl Acad Sci U S A 2025 Jan; 122(1): e2414707122.
• 2024
  Dulon D, de Monvel JB, Plion B, Mallet A, Petit C, Condamine S, Bouleau Y, Safieddine S, A free intravesicular C-terminal of otoferlin is essential for synaptic vesicle docking and fusion at auditory inner hair cell ribbon synapses., Prog Neurobiol 2024 Aug; 240(): 102658.
• 2024
  Barbosa Spinola CM, Boutet de Monvel J, Safieddine S, Lahlou G, Etournay R, In utero adeno-associated virus (AAV)-mediated gene delivery targeting sensory and supporting cells in the embryonic mouse inner ear., PLoS One 2024 ; 19(7): e0305742.
• 2024
  Ghizlene Lahlou, Charlotte Calvet, François Simon, Vincent Michel, Lauranne Alciato, Baptiste Plion, Jacques Boutet de Monvel, Marie-José Lecomte, Mathieu Beraneck, Christine Petit, Saaid Safieddine, Extended time frame for restoring inner ear function through gene therapy in Usher1G preclinical model, JCI Insight, 2024, 9 (3), pp.e169504. ⟨10.1172/jci.insight.169504⟩.
• 2023
  Amariutei AE, Jeng JY, Safieddine S, Marcotti W, Recent advances and future challenges in gene therapy for hearing loss., R Soc Open Sci 2023 Jun; 10(6): 230644.
• 2023
  Christine Petit, Crystel Bonnet, Saaïd Safieddine, Deafness: from genetic architecture to gene therapy, Nature Reviews Genetics, 2023, ⟨10.1038/s41576-023-00597-7⟩.
• 2023
  Lahlou G, Calvet C, Giorgi M, Lecomte MJ, Safieddine S, Towards the Clinical Application of Gene Therapy for Genetic Inner Ear Diseases., J Clin Med 2023 Jan; 12(3): .
• 2022
  Calvet C, Peineau T, Benamer N, Cornille M, Lelli A, Plion B, Lahlou G, Fanchette J, Nouaille S, Boutet de Monvel J, Estivalet A, Jean P, Michel V, Sachse M, Michalski N, Avan P, Petit C, Dulon D, Safieddine S, The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses., iScience 2022 Dec; 25(12): 105628.
• 2019
  Hardelin JP, Safieddine S, [Congenital deafness forms: progressing toward gene therapy?]., Med Sci (Paris) 2019 Dec; 35(12): 1213-1215.
• 2019
  Johnson SL, Safieddine S, Mustapha M, Marcotti W, Hair Cell Afferent Synapses: Function and Dysfunction., Cold Spring Harb Perspect Med 2019 Dec; 9(12): .
• 2019
  Schilder AGM, Su MP, Blackshaw H, Lustig L, Staecker H, Lenarz T, Safieddine S, Gomes-Santos CS, Holme R, Warnecke A, Hearing Protection, Restoration, and Regeneration: An Overview of Emerging Therapeutics for Inner Ear and Central Hearing Disorders., Otol Neurotol 2019 Jun; 40(5): 559-570.
• 2019
  Tertrais M, Bouleau Y, Emptoz A, Belleudy S, Sutton RB, Petit C, Safieddine S, Dulon D, Viral Transfer of Mini-Otoferlins Partially Restores the Fast Component of Exocytosis and Uncovers Ultrafast Endocytosis in Auditory Hair Cells of Otoferlin Knock-Out Mice., J Neurosci 2019 May; 39(18): 3394-3411.
• 2019
  Akil O, Dyka F, Calvet C, Emptoz A, Lahlou G, Nouaille S, Boutet de Monvel J, Hardelin JP, Hauswirth WW, Avan P, Petit C, Safieddine S, Lustig LR, Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model., Proc Natl Acad Sci U S A 2019 Mar; 116(10): 4496-4501.
• 2018
  Aubin Samacoits, Racha Chouaib, Adham Safieddine, Abdel-Meneem Traboulsi, Christophe Zimmer, Wei Ouyang, Marion Peter, Edouard Bertrand, Thomas Walter, Florian Mueller, A computational framework to study sub-cellular RNA localization, Nature Communications, 2018, 9 (1), pp.4584. ⟨10.1038/s41467-018-06868-w⟩.
• 2018
  Calvet C, Lahlou G, Safieddine S, [Gene therapy progress: hopes for Usher syndrome]., Med Sci (Paris) 2018 Oct; 34(10): 842-848.
• 2018
  Corns LF, Johnson SL, Roberts T, Ranatunga KM, Hendry A, Ceriani F, Safieddine S, Steel KP, Forge A, Petit C, Furness DN, Kros CJ, Marcotti W, Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation., Nat Commun 2018 Oct; 9(1): 4015.
• 2018
  Dulon D, Papal S, Patni P, Cortese M, Vincent PF, Tertrais M, Emptoz A, Tlili A, Bouleau Y, Michel V, Delmaghani S, Aghaie A, Pepermans E, Alegria-Prevot O, Akil O, Lustig L, Avan P, Safieddine S, Petit C, El-Amraoui A, Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome., J Clin Invest 2018 Aug; 128(8): 3382-3401.
• 2017
  Michalski N, Goutman JD, Auclair SM, Boutet de Monvel J, Tertrais M, Emptoz A, Parrin A, Nouaille S, Guillon M, Sachse M, Ciric D, Bahloul A, Hardelin JP, Sutton RB, Avan P, Krishnakumar SS, Rothman JE, Dulon D, Safieddine S, Petit C, Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses., Elife 2017 Nov; 6(): .
• 2017
  Emptoz A, Michel V, Lelli A, Akil O, Boutet de Monvel J, Lahlou G, Meyer A, Dupont T, Nouaille S, Ey E, Franca de Barros F, Beraneck M, Dulon D, Hardelin JP, Lustig L, Avan P, Petit C, Safieddine S, Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G., Proc Natl Acad Sci U S A 2017 Sep; 114(36): 9695-9700.
• 2017
  Philippe F.Y. Vincent, Yohan Bouleau, Gilles Charpentier, Alice Emptoz, Saaid Safieddine, Christine Petit, Didier Dulon, Different Ca V 1.3 Channel Isoforms Control Distinct Components of the Synaptic Vesicle Cycle in Auditory Inner Hair Cells, Journal of Neuroscience, 2017, 37 (11), pp.2960-2975. ⟨10.1523/JNEUROSCI.2374-16.2017⟩.
• 2015
  Delmaghani S, Defourny J, Aghaie A, Beurg M, Dulon D, Thelen N, Perfettini I, Zelles T, Aller M, Meyer A, Emptoz A, Giraudet F, Leibovici M, Dartevelle S, Soubigou G, Thiry M, Vizi ES, Safieddine S, Hardelin JP, Avan P, Petit C, Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes., Cell 2015 Nov; 163(4): 894-906.
• 2014
  P. Vincent, Y. Bouleau, S. Safieddine, Christine Petit, D. Dulon, Exocytotic Machineries of Vestibular Type I and Cochlear Ribbon Synapses Display Similar Intrinsic Otoferlin-Dependent Ca2+ Sensitivity But a Different Coupling to Ca2+ Channels, Journal of Neuroscience, 2014, 34 (33), pp.10853-10869. ⟨10.1523/JNEUROSCI.0947-14.2014⟩.
• 2013
  Meyer A, Petit C, Safieddine S, [Gene therapy for human hearing loss: challenges and promises]., Med Sci (Paris) 2013 Oct; 29(10): 883-9.
• 2012
  Safieddine S, El-Amraoui A, Petit C, The auditory hair cell ribbon synapse: from assembly to function., Annu Rev Neurosci 2012 ; 35(): 509-28.
• 2010
  Beurg M, Michalski N, Safieddine S, Bouleau Y, Schneggenburger R, Chapman ER, Petit C, Dulon D, Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells., J Neurosci 2010 Oct; 30(40): 13281-90.
• 2009
  Roux I, Hosie S, Johnson SL, Bahloul A, Cayet N, Nouaille S, Kros CJ, Petit C, Safieddine S, Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses., Hum Mol Genet 2009 Dec; 18(23): 4615-28.
• 2009
  Dulon D, Safieddine S, Jones SM, Petit C, Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapses., J Neurosci 2009 Aug; 29(34): 10474-87.
• 2008
  Kirian Legendre, Saaid Safieddine, Polonca Küssel-Andermann, Christine Petit, Aziz El-Amraoui, αII-βV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells, Journal of Cell Science, 2008, 121 (20), pp.3347-3356. ⟨10.1242/jcs.028134⟩.
• 2008
  Beurg M, Safieddine S, Roux I, Bouleau Y, Petit C, Dulon D, Calcium- and otoferlin-dependent exocytosis by immature outer hair cells., J Neurosci 2008 Feb; 28(8): 1798-803.
• 2008
  Michel Leibovici, Saaid Safieddine, Christine Petit, [Chapter 8] Mouse Models for Human Hereditary Deafness, Mouse Models of Developmental Genetic Disease, 84, Elsevier, pp.385-429, 2008, Current Topics in Developmental Biology, 978-0-12-374454-8. ⟨10.1016/S0070-2153(08)00608-X⟩.
• 2006
  Roux I, Safieddine S, Nouvian R, Grati M, Simmler MC, Bahloul A, Perfettini I, Le Gall M, Rostaing P, Hamard G, Triller A, Avan P, Moser T, Petit C, Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse., Cell 2006 Oct; 127(2): 277-89.
• 2006
  Isabelle Roux, Saaid Safieddine, Régis Nouvian, M'Hamed Grati, Marie-Christine Simmler, Amel Bahloul, Isabelle Perfettini, Morgane Le Gall, Phillipe Rostaing, Ghislaine Hamard, Antoine Triller, Paul Avan, Tobias Moser, Christine Petit, Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse., Cell, 2006, 127 (2), pp.277-89. ⟨10.1016/j.cell.2006.08.040⟩.
• 2002
  Lee HK, Safieddine S, Petralia RS, Wenthold RJ, Identification of a novel SNAP25 interacting protein (SIP30)., J Neurochem 2002 Jun; 81(6): 1338-47.
• 2002
  Eybalin M, Renard N, Aure F, Safieddine S, Cysteine-string protein in inner hair cells of the organ of Corti: synaptic expression and upregulation at the onset of hearing., Eur J Neurosci 2002 May; 15(9): 1409-20.
• 2002
  Wenthold RJ, Safieddine S, Ly CD, Wang YX, Lee HK, Wang CY, Kachar B, Petralia RS, Vesicle targeting in hair cells., Audiol Neurootol 2002 ; 7(1): 45-8.
• 2000
  Polonca Küssel-Andermann, Aziz El-Amraoui, Saaid Safieddine, Sylvie Nouaille, Isabelle Perfettini, Marc Lecuit, Pascale Cossart, Uwe Wolfrum, Christine Petit, Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex, EMBO Journal, 2000, 19 (22), pp.6020-6029. ⟨10.1093/emboj/19.22.6020⟩.
• 2000
  Polonca Küssel-Andermann, Aziz El-Amraoui, Saaid Safieddine, Jean-Pierre Hardelin, Sylvie Nouaille, Jacques Camonis, Christine Petit, Unconventional Myosin VIIA Is a Novel A-kinase-anchoring Protein, Journal of Biological Chemistry, 2000, 275 (38), pp.29654-29659. ⟨10.1074/jbc.M004393200⟩.
• 2000
  Kharkovets T, Hardelin JP, Safieddine S, Schweizer M, El-Amraoui A, Petit C, Jentsch TJ, KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway., Proc Natl Acad Sci U S A 2000 Apr; 97(8): 4333-8.
• 1992
  Safieddine S, Eybalin M, Triple Immunofluorescence Evidence for the Coexistence of Acetylcholine, Enkephalins and Calcitonin Gene-related Peptide Within Efferent (Olivocochlear) Neurons of Rats and Guinea-pigs., Eur J Neurosci 1992 ; 4(10): 981-992.