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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Oct 2018
Ending Date
30
Sep 2021
Status
Ongoing
Members
3
Structures
4
Instituts
1

About

Malaria vectors can only transmit malaria after getting infected when biting infectious people. The mosquito microbiota protects its host against infection by parasites and negatively affects the mosquito fitness, impacting the chance of transmission. So far, functional studies on the microbiota have been performed on laboratory mosquitoes whose microbiota composition does not reflect that of field mosquitoes. Alternatively, research based on field mosquitoes is descriptive or may at best identify correlations. Here, we will develop a model of laboratory mosquitoes to study the effect of the microbiota composition on malaria transmission in French Guiana. We will study the microbiota composition in wild Amazonian malaria vectors and reproduce simplified field types of microbiota (enterotypes) into laboratory-reared mosquitoes. Using these new models, we will study whether some enterotypes block or promote transmission by affecting the mosquito permissiveness to infection and fitness.

Fundings