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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
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  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
17
Jan 2023
Status
Ongoing
Members
5
Structures
3

About

Cytokinesis requires a complex series of cytoskeletal changes, including remodeling of the actin, septin, and microtubule cytoskeleton. This is essential for the assembly and constriction of the ESCRT-III filaments that drives the final abscission.

Specifically, we are interested in understanding how actin filaments are cleared at the abscission site, how actin/septin/ESCRTs are coordinated and how changes in lipids can control abscission.

For instance, we discovered that the oncogenic Rab35 GTPase, through different effectors, plays a key role in cytokinetic abscission. This involves phosphoinositide lipid hydrolysis by the PI(4,5)P2 phosphatase OCRL —which is mutated in patient suffering from the Oculo-Cerebro-Renal syndrome of Lowe— and actin depolymerization by the oxidoreductase MICAL1 —an enzyme that specifically oxidizes actin filaments to induce their disassembly. Our work revealed the first connection between oxidoreduction and cell division by triggering local actin depolymerization and thereby allowing ESCRT filament constriction at the abscission site.

To learn more, see our past publications:

Kouranti et al. Current Biology 2006

Miserey-Lenkei et al. Nature Cell Biology 2010

Dambournet et al. Nature Cell Biology 2011

Chesneau et al. Current Biology 2012

Cauvin et al. Current Biolgy 2016

Klinkert et al. Nature Communications 2016

Fremont et al. Nature Communications 2017

Ribet et al. Journal of Cell Biology 2017

Mondin et al. Journal of Cell Biology 2019

Bai et al. PNAS 2020

Addi et al. Nature Communications 2020

 

 

 

 

 

Fundings