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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
04
Feb 2015
Status
Completed
Members
4
Structures
1

About

In Escherichia coli and Salmonella enterica serovar Typhimurium, the regulatory protein Crl regulates gene expression by increasing the performance of RpoS/σS sigma factor to modify global gene transcription in stationary phase and under stress conditions. PFPR is involved in cloning different tagged constructions, producing and purifying RpoS and Crl of various species and mutant domains. Purified proteins were used for structural studies and in vitro assays to further assess the mechanism of Crl-σS interaction and its impact at the physiological level. ANR SIGMADAPT (2011-2015). Françoise Norel – Laboratoire Systèmes Macromoléculaires et Signalisation