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  • program_project
  • nrc
  • whocc
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  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
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  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Oct 2015
Status
Ongoing
Members
2
Structures
2

About

Overproduction of membrane proteins in the E. coli strains generally induce cell death. The multiple mutant C43 (DE3) derivative of BL21 (DE3) strain was selected to resist this overproduction. In this mutant,  the membrane protein of interest continues to be overproduced without  cell death or even stop growing, but, more, the cells accumulate, after a few hours of growth, intracellular membrane system, not connected to the plasma membrane of the cell, wherein the overexpressed membrane protein is inserted. This phenomenon of cell proliferation, described for the first time in the bacterium Escherichia coli, evokes, at least from the cytological point of view, the structures observed in the mitochondria.

 

Project in collaboration with Bruno Miroux and Marc Uzan,

UMR7099. Laboratoire de Physico-Chimie Moléculaire des Membranes Biologiques

Institut de Biologie Physico-chimique

13 rue Pierre et Marie Curie. 75005. Paris