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© Research
Project

Identification of cellular PDZ-containing Proteins targeted by the virus SARS-Cov-2 during infection (PPCOVi)

Team: Signalling and Molecular interactions
Department of: Neuroscience
Project leader: Nicolas Wolff
Member: Célia Caillet-Saguy
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
27
Apr 2020
Status
Ongoing
Members
2
Structures
2

About

Thanks to their binding to PDZ domains, viral proteins play an important role in the replication and pathogenesis of SARS-CoV. Through cellular and in vitro high-throughput tests, this project aims to identify the cellular proteins that would be targeted by these viral proteins during infection and to characterize the mechanism by which viral sequences compete with cellular interactions through PDZ domains.