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© Giulia Manina, Institut Pasteur
Mycobacterium tuberculosis dual fluorescent reporter of metabolic activity. Green (active bacilli) and red fluorescence (quiescent bacilli) are merged, 100X magnification.
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
07
Sep 2015
Status
Ongoing
Members
1
Structures
2

About

Maintenance of genome integrity is crucial for bacteria to survive under stressful conditions, such as host immune defenses and antibiotics. Exposure to DNA damage might enhance cell-to-cell heterogeneity, eventually leading to states of protracted quiescence. Analysis of DNA damage response within individual cells aims to decipher pathways critical for adaptation and persistence.

Fundings