Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© A-M. Pais-Correia, M-I. Thoulouze, A. Alcover, A. Gessain
Mise en évidence de structures de type "biofilm ", formées par le rétrovirus HTLV-1 générés par des cellules infectées (cellules du haut), qui ont été transmis à un autre lymphocyte (cellule du bas). Micrographie en microscopie électronique à balayage. Image colorisée.
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Feb 2007
Ending Date
31
Dec 2013
Status
Completed
Members
4
Structures
2
Publications
5

About

Perinatal HIV infection – ANRS-EP38-IMMIP

Potent combined antiretroviral therapy has transformed HIV disease into a stable chronic condition. Infected children born at the beginning of the epidemic are now reaching adulthood. The unique characteristics of perinatal infection described in children may be altered by long-term exposure to viral replication, various antiretroviral treatments and puberty. In 2007, we set up a collaborative study to study such patients with 10 clinical sites and the ANRS-CO-10 cohort that follows infected children since birth.

Our hypothesis was that the specificity of the period of infection and the whole disease history influence the following four immune mechanisms and their evolution under potent therapy: thymic activity that is a crucial factor for the immune response to new infections and vaccines; premature ageing of the immune system; immune activation; and HIV-specific T lymphocytes that control viral replication. The aim of the study was to characterise these immune parameters in perinatally infected subjects as they reach adulthood and to assess their association with current and past HIV disease, which is known since birth for these patients.

The 93 patients included were between 15 and 24 years of age at the time of the study. Seventy-nine (85%) patients were receiving cART and plasma HIV RNA was undetectable in 75% of the treated patients. Most patients had reached advanced stages of disease: 80% had had at least one CD4 cell percentage below 15% and only four of them had never received HAART.

The major result of this work was that naive CD4 T lymphocytes were present in proportion similar to those of uninfected young adults. Furthermore, neither naive CD4 T lymphocytes levels, nor the proportion of recent thymic emigrants were reduced in patients with viral replication. The level of total HIV DNA in PBMCs, which reflects the size of the viral reservoir, was associated with viral replication over the last 10 years. In contrast to reports in adults, the HIV DNA level was not associated with CD4 T cell counts.

Fundings

References