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  • PhD Student
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  • Post-doc
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  • Visiting Scientist
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  • Deputy Director of National Reference Center
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  • Director of Center
  • Director of Department
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© Research
Member: Group Leader

Sylvie Pochet

Projects

Project
Ongoing
8 Members

Inhibitors of bacterial NAD kinases

Sylvie Pochet (PI)

NAD mimics as potential antibacterial agents The NAD(P) biosynthesis pathways have attracted recent interest as a source of enzyme targets for the development of antimicrobial agents. Our own research focused on the structure-based development […]
Project
Ongoing
6 Members

Protein synthesis machinery of Trypanosomatid as a therapeutic target

Nadia Izadi-Pruneyre (PI)

Pathogenic protozoans of the trypanosomatid group still remain a major world health problem. Cycling between insect vectors and mammalian hosts, Trypanosoma cruzi is the causative agent of Chagas disease, while over 20 Leishmania species […]
Project
Completed
7 Members

Inhibitors of the 2’-deoxyribonucleotide N-hydrolase DNPH1, an enzyme involved in cellular growth and angiogenesis

Sylvie Pochet (PI)

Nucleoside analogues as potential antitumor agents. This project aims to characterize and validate the nucleotide N-hydrolase DNPH1 as a new target in oncology. Inhibition of Rcl alone or in combination with other chemotherapeutic drugs […]
Project
Completed
14 Members

FP7 Targeting the Leishmania kinome for the development of novel anti-parasitic strategies (LeishDrug)

Gérald Spaeth (PI)

Visceral leishmaniasis is caused by the protozoan parasites Leishmania donovani and Leishmania infantum and is a potentially fatal disease in endemic areas around the world. During the infectious cycle, Leishmania alternate between the insect […]
Project
Completed
8 Members

Inhibitors of Pseudomonas aeruginosa IMPDH

Sophie Vichier-Guerre (PI)

IMPDH from Pseudomonas aeruginosa (see Inosine-5′-monophosphate dehydrogenase project) was found to be allosterically regulated by MgATP (Labesse et al., 2013). The discovery of this mode of regulation of the catalytic activity, never described before […]
Project
Completed
5 Members

Inhibitors of TMPK from Mycobacterium tuberculosis

Hélène Munier-Lehmann (PI)

TMPK from Mycobacterium tuberculosis belongs to the NMPK family, which was chosen as potential targets for the development of new antimicrobials (see “Nucleoside monophosphate kinases” project). Based on the 3D-structure of TMPK from M. […]

Publications

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