Publications

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2019

Petrella S, Capton E, Raynal B, Giffard C, Thureau A, Bonneté F, Alzari PM, Aubry A, Mayer C, Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity, Structure 2019 04;27(4):579-589.e5.
2016

Brossier F, Boudinet M, Jarlier V, Petrella S, Sougakoff W, Comparative study of enzymatic activities of new KatG mutants from low- and high-level isoniazid-resistant clinical isolates of Mycobacterium tuberculosis, Tuberculosis (Edinb) 2016 09;100:15-24.
2016

Pantel A, Petrella S, Veziris N, Matrat S, Bouige A, Ferrand H, Sougakoff W, Mayer C, Aubry A, Description of compensatory gyrA mutations restoring fluoroquinolone susceptibility in Mycobacterium tuberculosis, J. Antimicrob. Chemother. 2016 May;.
2016

Stéphanie Petrella, Alexandra Aubry, Geneviève Janvier, Eloi Paul Coutant, Alex Cartier, Thuy-Ha Dao, Frédéric Bonhomme, Laurence Motreff, Cédric Pissis, Chantal Bizet, Dominique Clermont, Evelyne Begaud, Pascal Retailleau, Hélène Munier-Lehmann, Estelle Capton, Claudine Mayer, Yves Janin, Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors, Can. J. Chem. 2016, 94 , 240-250.
2013

Agrawal A, Roué M, Spitzfaden C, Petrella S, Aubry A, Hann M, Bax B, Mayer C, Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion, Biochem. J. 2013 Dec;456(2):263-73.
2013

Bouige A, Darmon A, Piton J, Roue M, Petrella S, Capton E, Forterre P, Aubry A, Mayer C, Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes, Biochem. J. 2013 Nov;455(3):285-94.
2012

Segala E, Sougakoff W, Nevejans-Chauffour A, Jarlier V, Petrella S, New mutations in the mycobacterial ATP synthase: new insights into the binding of the diarylquinoline TMC207 to the ATP synthase C-ring structure, Antimicrob. Agents Chemother. 2012 May;56(5):2326-34.
2012

Pantel A, Petrella S, Veziris N, Brossier F, Bastian S, Jarlier V, Mayer C, Aubry A, Extending the definition of the GyrB quinolone resistance-determining region in Mycobacterium tuberculosis DNA gyrase for assessing fluoroquinolone resistance in M. tuberculosis, Antimicrob. Agents Chemother. 2012 Apr;56(4):1990-6.
2012

Darmon A, Piton J, Roué M, Petrella S, Aubry A, Mayer C, Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase CTD, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2012 Feb;68(Pt 2):178-80.
2011

Pantel A, Petrella S, Matrat S, Brossier F, Bastian S, Reitter D, Jarlier V, Mayer C, Aubry A, DNA gyrase inhibition assays are necessary to demonstrate fluoroquinolone resistance secondary to gyrB mutations in Mycobacterium tuberculosis, Antimicrob. Agents Chemother. 2011 Oct;55(10):4524-9.
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Stéphanie Petrella

• Structural Microbiology • Type II topoisomerases challenges

Projects

MM4TB

ATPase inhibitors, the cases of human heat shock protein 90 and bacterial type IIA topoisomerases

Structural studies of type II topoisomerases

Publications