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2024Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase., iScience 2024 Oct; 27(10): 110967.
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2023The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG., Nucleic Acids Res 2023 Apr; 51(7): 3288-3306.
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2022Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states., Nat Commun 2022 01; 13(1): 59.
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2021A systematic review of Mycobacterium leprae DNA gyrase mutations and their impact on fluoroquinolone resistance., Clin Microbiol Infect 2021 Nov; 27(11): 1601-1612.
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2020Structure-Based Drug Design for Tuberculosis: Challenges Still Ahead, Appl. Sci. 2020; 10(12):4248.
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2019Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity, Structure 2019 04;27(4):579-589.e5.
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2016Comparative study of enzymatic activities of new KatG mutants from low- and high-level isoniazid-resistant clinical isolates of Mycobacterium tuberculosis, Tuberculosis (Edinb) 2016 09;100:15-24.
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2016Description of compensatory gyrA mutations restoring fluoroquinolone susceptibility in Mycobacterium tuberculosis, J. Antimicrob. Chemother. 2016 May;.
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2016Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors, Can. J. Chem. 2016, 94 , 240-250.
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2013Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion, Biochem. J. 2013 Dec;456(2):263-73.
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2013Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes, Biochem. J. 2013 Nov;455(3):285-94.
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2012New mutations in the mycobacterial ATP synthase: new insights into the binding of the diarylquinoline TMC207 to the ATP synthase C-ring structure, Antimicrob. Agents Chemother. 2012 May;56(5):2326-34.
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2012Extending the definition of the GyrB quinolone resistance-determining region in Mycobacterium tuberculosis DNA gyrase for assessing fluoroquinolone resistance in M. tuberculosis, Antimicrob. Agents Chemother. 2012 Apr;56(4):1990-6.
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2012Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase CTD, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2012 Feb;68(Pt 2):178-80.
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2011DNA gyrase inhibition assays are necessary to demonstrate fluoroquinolone resistance secondary to gyrB mutations in Mycobacterium tuberculosis, Antimicrob. Agents Chemother. 2011 Oct;55(10):4524-9.
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2011Crystal structure of the pyrazinamidase of Mycobacterium tuberculosis: insights into natural and acquired resistance to pyrazinamide, PLoS ONE 2011;6(1):e15785.
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2010Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase, PLoS ONE 2010 Aug;5(8):e12245.
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2010Conservation of HHV-6 DNA polymerase processivity factor sequence and predicted structure suggests it as a target for antiviral development, Antiviral Res. 2010 Jun;86(3):316-9.
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2009Specific structural features of the N-acetylmuramoyl-L-alanine amidase AmiD from Escherichia coli and mechanistic implications for enzymes of this family, J. Mol. Biol. 2010 Mar;397(1):249-59.
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2009Purification, crystallization and preliminary X-ray diffraction experiments on the breakage-reunion domain of the DNA gyrase from Mycobacterium tuberculosis, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009 Nov;65(Pt 11):1182-6.
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2008Crystal structure and activity of Bacillus subtilis YoaJ (EXLX1), a bacterial expansin that promotes root colonization, Proc. Natl. Acad. Sci. U.S.A. 2008 Nov;105(44):16876-81.
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2008Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France, Antimicrob. Agents Chemother. 2008 Oct;52(10):3725-36.
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2007Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide, J. Mol. Biol. 2007 Aug;371(2):528-39.
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2007Expression and purification of an active form of the Mycobacterium leprae DNA gyrase and its inhibition by quinolones, Antimicrob. Agents Chemother. 2007 May;51(5):1643-8.
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2007Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet, Antivir. Ther. (Lond.) 2007;12(6):877-88.
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2006Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria, Antimicrob. Agents Chemother. 2006 Aug;50(8):2853-6.
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2005Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins, J. Biol. Chem. 2005 Sep;280(35):31249-56.
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2003Crystallization and preliminary X-ray diffraction study of the class A beta-lactamase SED-1 and its mutant SED-G238C from Citrobacter sedlakii, Acta Crystallogr. D Biol. Crystallogr. 2004 Jan;60(Pt 1):125-8.
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2001Novel class A beta-lactamase Sed-1 from Citrobacter sedlakii: genetic diversity of beta-lactamases within the Citrobacter genus, Antimicrob. Agents Chemother. 2001 Aug;45(8):2287-98.
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2001Crystal structures of the class D beta-lactamase OXA-13 in the native form and in complex with meropenem, J. Mol. Biol. 2001 Jul;310(4):859-74.