Timeline

Stéphanie Petrella

Permanent Researcher

24 Apr 2023

publication

The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG.

26 Jan 2022

team

Bacterial Cell Cycle Mechanisms

10 Jan 2022

publication

Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states.

01 Nov 2021

publication

A systematic review of Mycobacterium leprae DNA gyrase mutations and their impact on fluoroquinolone resistance.

20 Jun 2020

publication

Structure-Based Drug Design for Tuberculosis: Challenges Still Ahead

07 Feb 2019

publication

Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity

16 Jun 2016

publication

Comparative study of enzymatic activities of new KatG mutants from low- and high-level isoniazid-resistant clinical isolates of Mycobacterium tuberculosis

27 May 2016

publication

Description of compensatory gyrA mutations restoring fluoroquinolone susceptibility in Mycobacterium tuberculosis

20 Jan 2016

project

MM4TB

01 Jan 2016

publication

Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors

28 Jul 2015

project

ATPase inhibitors, the cases of human heat shock protein 90 and bacterial type IIA topoisomerases

03 Jul 2015

project

Structural studies of type II topoisomerases

11 May 2015

team

Structural Microbiology

01 Dec 2013

publication

Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion

01 Nov 2013

publication

Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes

21 Feb 2012

publication

New mutations in the mycobacterial ATP synthase: new insights into the binding of the diarylquinoline TMC207 to the ATP synthase C-ring structure

30 Jan 2012

publication

Extending the definition of the GyrB quinolone resistance-determining region in Mycobacterium tuberculosis DNA gyrase for assessing fluoroquinolone resistance in M. tuberculosis

26 Jan 2012

publication

Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase CTD

18 Jul 2011

publication

DNA gyrase inhibition assays are necessary to demonstrate fluoroquinolone resistance secondary to gyrB mutations in Mycobacterium tuberculosis

24 Jan 2011

publication

Crystal structure of the pyrazinamidase of Mycobacterium tuberculosis: insights into natural and acquired resistance to pyrazinamide

18 Aug 2010

publication

Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase

16 Mar 2010

publication

Conservation of HHV-6 DNA polymerase processivity factor sequence and predicted structure suggests it as a target for antiviral development

28 Dec 2009

publication

Specific structural features of the N-acetylmuramoyl-L-alanine amidase AmiD from Escherichia coli and mechanistic implications for enzymes of this family

30 Oct 2009

publication

Purification, crystallization and preliminary X-ray diffraction experiments on the breakage-reunion domain of the DNA gyrase from Mycobacterium tuberculosis

29 Oct 2008

publication

Crystal structure and activity of Bacillus subtilis YoaJ (EXLX1), a bacterial expansin that promotes root colonization

14 Jul 2008

publication

Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France

02 Jun 2007

publication

Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide

26 Feb 2007

publication

Expression and purification of an active form of the Mycobacterium leprae DNA gyrase and its inhibition by quinolones

01 Jan 2007

publication

Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet

01 Aug 2006

publication

Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria

29 Jun 2005

publication

Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins

18 Dec 2003

publication

Crystallization and preliminary X-ray diffraction study of the class A beta-lactamase SED-1 and its mutant SED-G238C from Citrobacter sedlakii

01 Aug 2001

publication

Novel class A beta-lactamase Sed-1 from Citrobacter sedlakii: genetic diversity of beta-lactamases within the Citrobacter genus

20 Jul 2001

publication

A little guide for advanced search:

Timeline

The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG.

Bacterial Cell Cycle Mechanisms

Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states.

A systematic review of Mycobacterium leprae DNA gyrase mutations and their impact on fluoroquinolone resistance.

Structure-Based Drug Design for Tuberculosis: Challenges Still Ahead

Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity

Comparative study of enzymatic activities of new KatG mutants from low- and high-level isoniazid-resistant clinical isolates of Mycobacterium tuberculosis

Description of compensatory gyrA mutations restoring fluoroquinolone susceptibility in Mycobacterium tuberculosis

MM4TB

Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors

ATPase inhibitors, the cases of human heat shock protein 90 and bacterial type IIA topoisomerases

Structural studies of type II topoisomerases

Structural Microbiology

Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion

Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes

New mutations in the mycobacterial ATP synthase: new insights into the binding of the diarylquinoline TMC207 to the ATP synthase C-ring structure

Extending the definition of the GyrB quinolone resistance-determining region in Mycobacterium tuberculosis DNA gyrase for assessing fluoroquinolone resistance in M. tuberculosis

Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase CTD

DNA gyrase inhibition assays are necessary to demonstrate fluoroquinolone resistance secondary to gyrB mutations in Mycobacterium tuberculosis

Crystal structure of the pyrazinamidase of Mycobacterium tuberculosis: insights into natural and acquired resistance to pyrazinamide

Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase

Conservation of HHV-6 DNA polymerase processivity factor sequence and predicted structure suggests it as a target for antiviral development

Specific structural features of the N-acetylmuramoyl-L-alanine amidase AmiD from Escherichia coli and mechanistic implications for enzymes of this family

Purification, crystallization and preliminary X-ray diffraction experiments on the breakage-reunion domain of the DNA gyrase from Mycobacterium tuberculosis

Crystal structure and activity of Bacillus subtilis YoaJ (EXLX1), a bacterial expansin that promotes root colonization

Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France

Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide

Expression and purification of an active form of the Mycobacterium leprae DNA gyrase and its inhibition by quinolones

Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet

Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria

Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins

Crystallization and preliminary X-ray diffraction study of the class A beta-lactamase SED-1 and its mutant SED-G238C from Citrobacter sedlakii

Novel class A beta-lactamase Sed-1 from Citrobacter sedlakii: genetic diversity of beta-lactamases within the Citrobacter genus

Crystal structures of the class D beta-lactamase OXA-13 in the native form and in complex with meropenem