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© Emeline Camand
Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. APC est un supresseur de tumeur qui est impliqué dans la polarisation des astrocytes normaux. La localisation d'APC est altérée dans des lignées de gliomes. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaire.

Projects

Project
Ongoing
6 Members

Cytoskeleton and Mechanobiology projects

Sandrine Etienne-Manneville (PI)

Until now, the role of actin in cell migration has been extensively studied, but much less is known about the role of microtubules and Intermediate Filaments(IFs) (Dutour-Provenzano and Etienne-Manneville, 2021, 34033784; Etienne-Manneville, 2018, 30059630). […]
Project
Ongoing
3 Members

Covid19 related project

Sandrine Etienne-Manneville (PI)

Role of the E-protein in intracellular viral behavior  (Batiste Boëda, INSERM) The coronavius genome encodes four major structural proteins: the spike (S) protein, nucleocapsid (N) protein, membrane (M) protein, and the envelope (E) protein. […]
Project
Ongoing
6 Members

Cell Polarity projects

Sandrine Etienne-Manneville (PI)

  What are the central components of polarity pathways ? Are they affected during gliomagenesis? Using astrocyte directed migration as a model system, we have identified evolutionary conserved polarity signals that control cell polarity […]
Project
Completed
2 Members

Reorganization of cytoskeletal elements and cell migration – Perturbation of the regulation of cytoskeletal networks in glioblastoma cells

Sandrine Etienne-Manneville (PI)

How are cytoskeletal elements reorganized to promote cell migration? Is the regulation of the cytoskeletal networks perturbed in glioblastoma cells? We have shown that the three main cytoskeletal networks, microfilaments, microtubules and intermediate filaments […]
Project
Ongoing
2 Members

Determining the central components of polarity pathways and their affection during gliomagenesis

Sandrine Etienne-Manneville (PI)

What are the central components of polarity pathways ? Are they affected during gliomagenesis? Using astrocyte directed migration as a model system, we have identified evolutionary conserved polarity signals that control cell polarity and […]
Project
Ongoing
2 Members

Role and dynamics of cell-cell interactions during cell polarization and collective directed migration

Sandrine Etienne-Manneville (PI)

What are the role and the dynamics of cell-cell interactions during cell polarization and collective directed migration? How loss of cellular interactions affects the migratory behavior of glioblastoma cells? We have shown that the […]

Publications

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