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Host parasite metabolic interactions
Liliana Mancio Silva (PI)
In this research project, we seek to understand whether malaria-causing Plasmodium parasites i) use sensing mechanisms to select the hepatocyte where its replication will unfold and/or ii) promote host metabolic reprogramming upon invasion of […]
2018Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin, Nat Microbiol 2018 Nov;3(11):1224-1233.
2017Immunological memory to blood-stage malaria infection is controlled by the histamine releasing factor (HRF) of the parasite, Sci Rep 2017 08;7(1):9129.
2016Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes, Cell Host Microbe 2016 Nov;20(5):618-630.
2014Plasmodium berghei histamine-releasing factor favours liver-stage development via inhibition of IL-6 production and associates with a severe outcome of disease, Cell. Microbiol. 2015 Apr;17(4):542-58.
2014ZIPCO, a putative metal ion transporter, is crucial for Plasmodium liver-stage development, EMBO Mol Med 2014 Nov;6(11):1387-97.
2013Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion, Nat Commun 2013;4:2552.
2011Independent roles of apical membrane antigen 1 and rhoptry neck proteins during host cell invasion by apicomplexa, Cell Host Microbe 2011 Dec;10(6):591-602.
2007In vivo imaging of malaria parasites in the murine liver, Nat Protoc 2007;2(7):1811-8.
2007Imaging malaria sporozoites in the dermis of the mammalian host, Nat Protoc 2007;2(7):1705-12.