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© Research
Publication : Scientific reports

Immunological memory to blood-stage malaria infection is controlled by the histamine releasing factor (HRF) of the parasite

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Scientific reports - 22 Aug 2017

Demarta-Gatsi C, Peronet R, Smith L, Thiberge S, Ménard R, Mécheri S

Link to Pubmed [PMID] – 28831137

Sci Rep 2017 08;7(1):9129

While most subunit malaria vaccines provide only limited efficacy, pre-erythrocytic and erythrocytic genetically attenuated parasites (GAP) have been shown to confer complete sterilizing immunity. We recently generated a Plasmodium berghei (PbNK65) parasite that lacks a secreted factor, the histamine releasing factor (HRF) (PbNK65 hrfΔ), and induces in infected mice a self-resolving blood stage infection accompanied by a long lasting immunity. Here, we explore the immunological mechanisms underlying the anti-parasite protective properties of the mutant PbNK65 hrfΔ and demonstrate that in addition to an up-regulation of IL-6 production, CD4 but not CD8 T effector lymphocytes are indispensable for the clearance of malaria infection. Maintenance of T cell-associated protection is associated with the reduction in CD4PD-1 and CD8PD-1 T cell numbers. A higher number of central and effector memory B cells in mutant-infected mice also plays a pivotal role in protection. Importantly, we also demonstrate that prior infection with WT parasites followed by a drug cure does not prevent the induction of PbNK65 hrfΔ-induced protection, suggesting that such protection in humans may be efficient even in individuals that have been infected and who repeatedly received antimalarial drugs.

https://www.ncbi.nlm.nih.gov/pubmed/28831137