Proof of concept of the impact of gut microbiota in the clinical outcome of ICB in mouse models of cancer
We aim to study the adjuvant effects of Enterococcus hirae in antitumoral response. In particular, we want to identify how E. hirae translocates the intestinal barrier and the cells that mediate the antitumor effect.
What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]
The role of peptidoglycan in bacterial cell physiology: from bacterial shape to host-microbe interactions Peptidoglycan (PGN) is a major essential and unique component of the cell wall of both of Gram-negative and Gram-positive bacteria. […]
When Gut Bacteria Changes Brain Functions
We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]
Biology and Genetics of Bacterial Cell Wall
Our research unit aims at studying peptidoglycan (PGN) metabolism to better understand how bacteria assemble a mature and essential PGN that confers rigidity and shape to the cell despite a highly dynamic process […]
2023Microbiota-induced active translocation of peptidoglycan across the intestinal barrier dictates its within-host dissemination., Proc Natl Acad Sci U S A 2023 Jan; 120(4): e2209936120.
2022Bacterial sensing via neuronal Nod2 regulates appetite and body temperature., Science 2022 04; 376(6590): eabj3986.
2020Uptake, recognition and responses to peptidoglycan in the mammalian host., FEMS Microbiol. Rev. 2020 Sep; (): .
2020Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis., Elife 2020 Feb; 9(): .
2015Paenibacillus faecis sp. nov., isolated from human faeces., Int J Syst Evol Microbiol 2015 Dec; 65(12): 4621-4626.
2014Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, of cell wall-modifying enzymes, J. Bacteriol. 2014 Nov;196(21):3756-67.
2014The biology of bacterial peptidoglycans and their impact on host immunity and physiology, Cell. Microbiol. 2014 Jul;16(7):1014-23.
2014The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling, Cell Host Microbe 2014 May;15(5):623-35.