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Quality Control at the Ribosome
Micheline Fromont-Racine (PI)
Gene expression is controlled and regulated by nuclear and cytoplasmic surveillance mechanisms in order to preserve the integrity of genetic information. Some of the mechanisms occur in the nucleus during transcription and maturation of […]
2017The ribosome-bound quality control complex: from aberrant peptide clearance to proteostasis maintenance, Curr. Genet. 2017 Dec;63(6):997-1005.
2017The ribosome-bound quality control complex remains associated to aberrant peptides during their proteasomal targeting and interacts with Tom1 to limit protein aggregation, Mol. Biol. Cell 2017 May;28(9):1165-1176.
2016The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex, Science 2016 12;354(6318):1431-1433.
2016Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits, J. Biol. Chem. 2016 Jun;291(23):12245-53.