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© Mélanie Falord, Tarek Msadek, Jean-Marc Panaud
Staphylococcus aureus "golden staph" in scanning electron microscopy.
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 20 Nov 2017

Devaux L, Kaminski PA, Trieu-Cuot P, Firon A

Link to Pubmed [PMID] – 29169058

Curr. Opin. Microbiol. 2018 Feb;41:21-28

Cyclic di-AMP (c-di-AMP) is a bacterial signaling nucleotide synthesized by several human pathogens. This widespread and specific bacterial product is recognized by infected host cells to trigger an innate immune response. Detection of c-di-AMP in the host cytosol leads primarily to the induction of type I interferon via the STING-cGAS signaling axis, while being also entangled in the activation of the NF-κB pathway. During their long-standing interaction, host and pathogens have co-evolved to control c-di-AMP activation of innate immunity. On the bacterial side, the quantity of c-di-AMP released inside cells allows to manipulate the host response to exacerbate infection by avoiding immune recognition or, at the opposite, by overloading the STING-cGAS pathway.

https://www.ncbi.nlm.nih.gov/pubmed/29169058