Fluorescence microscopy is a defining technology in cellular biology but the diffraction of light limits the resolution of standard microscopes to ~200 nm, thus preventing detailed analyses of molecular structures. We are actively interested […]
Nuclear architecture and function
The one-dimensional sequence of the genome is carried by long polymers (chromosomes), which fold in the three dimensional volume of the nucleus. How this folding occurs and what it implies for genome function remains […]
Nucloc: mapping gene territories in the yeast nucleus
We have developed a series of software tools to compute and analyze the positions of genomic loci from thousands of yeast cells observed in fluorescence microscopy. These tools are available freely to academic and […]
2021Single-molecule localization microscopy, 1 (1), 1-27.
2017GPI-anchored proteins are confined in subdiffraction clusters at the apical surface of polarized epithelial cells, Biochem. J. 2017 12;474(24):4075-4090.
2017Functional organization of cytoplasmic inclusion bodies in cells infected by respiratory syncytial virus, Nat Commun 2017 09;8(1):563.