I am a permanent researcher focusing on the understanding of the structure-function relationships of the human nicotinic receptors, and their role psychiatric and neurological diseases.
My work explores the α5 and α7 containing nicotinic receptors subtypes. α5-receptors are involved in nicotine addiction and lung cancer while the α7 subtypes play fundamental roles in psychiatric disorders such as schizophrenia or Alzheimer’s disease. I combine biochemistry, X-ray crystallography, cryo-electron microscopy, biophysics and functional assays to elucidate their mechanisms of action in the human brain.
