Eugene Gladyshev obtained his Master degree from Yale University and PhD from Harvard University (under the supervision of Pr. Matthew Meselson). He subsequently joined the laboratory of Pr. Nancy Kleckner (Harvard University) as a Helen Hay Whitney Foundation fellow. Using the phenomenon of Repeat Induced Point mutation (RIP) in the fungus Neurospora crassa as a model system, he discovered the existence of a new kind of DNA homology-recognition process that is cardinally different from the canonical, recombination-mediated mechanism. In 2017, Dr. Gladyshev joined the Department of Mycology at the Institut Pasteur as a head of the Fungal Epigenomics Group, where he continues to use N. crassa as a model system to elucidate the molecular mechanisms of various epigenetic phenomena involving homologous DNA sequences.
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2024Remodeling of perturbed chromatin can initiate de novo transcriptional and post-transcriptional silencing., Proc Natl Acad Sci U S A 2024 Jul; 121(31): e2402944121.
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2023C-DNA may facilitate homologous DNA pairing., Trends Genet 2023 Jul; 39(7): 575-585.
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2021Modulation of C-to-T mutation by recombination-independent pairing of closely positioned DNA repeats., Biophys J 2021 10; 120(20): 4325-4336.
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2021Recombination-independent recognition of DNA homology for meiotic silencing in Neurospora crassa., Proc Natl Acad Sci U S A 2021 08; 118(33):e2108664118.
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2020Developing a tetO/TetR system in Neurospora crassa., Fungal Genet Biol 2020 03; 136(): 103316.
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2020Direct Homologous dsDNA-dsDNA Pairing: How, Where, and Why?, J Mol Biol 2020 02; 432(3): 737-744.
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2018Partition of Repeat-Induced Point Mutations Reveals Structural Aspects of Homologous DNA-DNA Pairing, Biophys. J. 2018 Jul;.
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2017Repeat-Induced Point Mutation and Other Genome Defense Mechanisms in Fungi, Microbiol Spectr 2017 Jul;5(4).
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2017DNA sequence homology induces cytosine-to-thymine mutation by a heterochromatin-related pathway in Neurospora, Nat. Genet. 2017 Jun;49(6):887-894.
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2016Recombination-independent recognition of DNA homology for repeat-induced point mutation, Curr. Genet. 2017 Jun;63(3):389-400.
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