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© Research
Publication : Microbiology spectrum

Repeat-Induced Point Mutation and Other Genome Defense Mechanisms in Fungi

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbiology spectrum - 01 Jul 2017

Gladyshev E

Link to Pubmed [PMID] – 28721856

Microbiol Spectr 2017 Jul;5(4)

Transposable elements have colonized the genomes of nearly all organisms, including fungi. Although transposable elements may sometimes provide beneficial functions to their hosts their overall impact is considered deleterious. As a result, the activity of transposable elements needs to be counterbalanced by the host genome defenses. In fungi, the primary genome defense mechanisms include repeat-induced point mutation (RIP) and methylation induced premeiotically, meiotic silencing by unpaired DNA, sex-induced silencing, cosuppression (also known as somatic quelling), and cotranscriptional RNA surveillance. Recent studies of the filamentous fungus Neurospora crassa have shown that the process of repeat recognition for RIP apparently involves interactions between coaligned double-stranded segments of chromosomal DNA. These studies have also shown that RIP can be mediated by the conserved pathway that establishes transcriptional (heterochromatic) silencing of repetitive DNA. In light of these new findings, RIP emerges as a specialized case of the general phenomenon of heterochromatic silencing of repetitive DNA.

https://www.ncbi.nlm.nih.gov/pubmed/28721856