My core interest is to understand how the brain organizes itself and forms memories in response to sensory inputs experienced during behavior. Several brain regions are involved in these processes. In particular, communication between the hippocampus and the prefrontal cortex (PFC) is critical for several fundamental memory functions, such as integrating accounts of experience, navigating towards known goals, encoding and consolidating memories, or retrieving them to guide future decisions. My goal is to identify the neuronal mechanisms underlying goal-directed navigation and spatial working memory. Here, I am combing my previous expertise with novel cutting-edge electrophysiological and optical recordings in behaving animals. My studies will be of critical importance for a detailed understanding of memory formation and consolidation.
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Timeline
CV
2017-now Postdoc, Department of Neuroscience, Institute Pasteur, Paris;
2011-2016 Postdoc, IINS institute, CNRS & Bordeaux University, Bordeaux;
2004-2010 Master&Ph.D, Institute of Neurobiology, Fudan University, Shanghai;
Publications
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2021Inhibitory control of synaptic signals preceding motor action in mouse frontal cortex, bioRxiv 10.1101/2021.07.05.451151.
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2018Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models, Nature Communications: Volume 9, Article number: 4272 (2018).
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2017Protein Kinase A deregulation in the medial prefrontal cortex impairs working memory in murine Oligophrenin1 deficiency, J. Neurosci. 2017 Oct;.
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2017Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors, Nature 2017 Sep;549(7672):384-388.
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2014The hippocampo-amygdala control of contextual fear expression is affected in a model of intellectual disability, Brain Struct Funct 2015 Nov;220(6):3673-82.
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2014Coronin 1 regulates cognition and behavior through modulation of cAMP/protein kinase A signaling, PLoS Biol. 2014 Mar;12(3):e1001820.
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2013Target-specific vulnerability of excitatory synapses leads to deficits in associative memory in a model of intellectual disorder, J. Neurosci. 2013 Aug;33(34):13805-19.
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2012Methylphenidate enhances NMDA-receptor response in medial prefrontal cortex via sigma-1 receptor: a novel mechanism for methylphenidate action, PLoS ONE 2012;7(12):e51910.
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2007Pre- and postsynaptic beta-adrenergic activation enhances excitatory synaptic transmission in layer V/VI pyramidal neurons of the medial prefrontal cortex of rats, Cereb. Cortex 2008 Jul;18(7):1506-20.