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© Shalin E. Abraham, Michael Häusser, Christoph Schmidt-Hieber, University College London
The dentate gyrus is one of the few mammalian brain regions where new neurons are generated throughout life. The image was taken with a confocal microscope from a parasagittal slice of the mouse hippocampus. Cells were labelled with fluorescent markers: Newly generated neurons are red (doublecortin), mature neurons are green (NeuN), and nuclei are blue (DAPI)
Publication : Neuron

Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Neuron - 28 Jan 2022

Zheng Z, Guo C, Li M, Yang L, Liu P, Zhang X, Liu Y, Guo X, Cao S, Dong Y, Zhang CL, Chen M, Xu J, Hu H, Cui Y

Link to Pubmed [PMID] – 35114101

Link to DOI – 10.1016/j.neuron.2022.01.011

Neuron. 2022 April; 110(8):1400-1415.e6

Chronic stress is a major risk factor for depression onset. However, it remains unclear how repeated stress sculpts neural circuits and finally elicits depression. Given the essential role of lateral habenula (LHb) in depression, here, we attempt to clarify how LHb-centric neural circuitry integrates stress-related information. We identify lateral hypothalamus (LH) as the most physiologically relevant input to LHb under stress. LH neurons fire with a unique pattern that efficiently drives postsynaptic potential summation and a closely followed LHb bursting (EPSP-burst pairing) in response to various stressors. We found that LH-LHb synaptic potentiation is determinant in stress-induced depression. Mimicking this repeated EPSP-burst pairings at LH-LHb synapses by photostimulation, we artificially induced an “emotional status” merely by potentiating this pathway in mice. Collectively, these results delineate the spatiotemporal dynamics of chronic stress processing from forebrain onto LHb in a pathway-, cell-type-, and pattern-specific manner, shedding light on early interventions before depression onset.

https://pubmed.ncbi.nlm.nih.gov/35114101