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© Research
Member: Permanent Researcher - Alumni

Alphonse Garcia

• Design for Biology

Alumni
Group: Design for Biology
Scientific Fields
Diseases
Organisms
Applications
Technique

Projects

Project
Ongoing
2 Members

PP2A1 is a target for Alzheimer disease

Alphonse Garcia (PI)

  PP2A1 is the Tau phosphatase that can inactivate the specific neurodegenerative pathways resulting from hyperphosphorylation of the neuronal Tau protein. In collaboration with JH Colle (Institut Pasteur) we will analyze the effect of […]
Project
Ongoing
2 Members

PP2A a key target for viruses

Alphonse Garcia (PI)

We recently proposed that specific targeting of PP2A holoenzymes by viral proteins is a general biological strategy, used by various viruses (from DNA tumour viruses to HIV-1) to specifically deregulate intracellular pathways of their […]
Project
Ongoing
2 Members

The trimeric ABαC phosphatase named PP2A1 is a target for cancer therapy

Alphonse Garcia (PI)

Constitutive activity of the PI3K-Akt pathway is often associated with resistance to cancer therapies. Importantly PP2A1 is the Akt phosphatase that can inactivate this survival pathway associated with cancer progression. In this regard in […]
Project
Ongoing
2 Members

PP2A a key target for viruses

Alphonse Garcia (PI)

We recently proposed that specific targeting of PP2A holoenzymes by viral proteins is a general biological strategy, used by various viruses (from DNA tumour viruses to HIV-1) to specifically deregulate intracellular pathways of their […]

Publications

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