Adeline Feri

After obtaining her Master degree in Genetics at the Paris Diderot University (European Magistere of Genetics) in 2013, Adeline Feri has started her PhD training under the supervision of Mélanie Legrand in the Fungal Biology and Pathogenicity Unit headed by Christophe d’Enfert. She is investigating genome stability and more precisely loss-of-heterozygosity (LOH) events in the human fungal pathogen Candida albicans.  Using the I-SceI meganuclease, Adeline has developed a system allowing the induction of DNA double-strand breaks at a unique site in the C. albicans genome. In parallel, she also constructed a collection of overexpression plasmids carrying genes involved in DNA processes and signalling pathways. She has conducted a screen to identify genes whose overexpression results either in an increase of the basal LOH rate in a wild-type condition or in a diminution of the high LOH frequency induced by stress exposure (H₂O₂, high temperature, antifungals) or I-SceI expression. This work aims to identify and characterize new signalling pathways controling genome dynamics in this species.