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Club viro: Oropouche virus & tropism /// Pfizer vaccine & new VOC of SARS-CoV-2

Microbiology department seminar : Sanne Klompe (Institut Pasteur) ; “RNA-guided DNA integration by CRISPR-associated transposons” ; Friday 29 September @11.30 am; Amphitheater Duclaux

© Research

Event

The twilight zone between transposons and endogenous retroviruses

Team: Molecular diversity of microbes

Member: Aude Bernheim

Member: Alba Herrero del Valle

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

24

Oct 2023

Time

10:00:00

Address

Room: Salle CFJ 28-01-01A - C. François Jacob 1er 01A

Location

2023-10-24 10:00:00 2023-10-24 11:00:00 Europe/Paris The twilight zone between transposons and endogenous retroviruses Seminar Maya Voichek: The twilight zone between transposons and endogenous retroviruses Endogenous retroviruses are abundantly embedded within host genomes and provide a unique snapshot of multiple past viral infections. They are thought to be […] Aude Bernheim aude.bernheim@pasteur.fr

Speakers

(Brennecke lab, IMBA, Vienna)

About

Seminar Maya Voichek: The twilight zone between transposons and endogenous retroviruses

Endogenous retroviruses are abundantly embedded within host genomes and provide a unique snapshot of multiple past viral infections. They are thought to be evolutionarily related and structurally similar to LTR retrotransposons, yet retroviruses primarily differ by a canonical Envelope gene crucial for infectivity. We have discovered a group of active transposons in the Drosophila ovary that mimic retroviral behavior – demonstrating infectivity traits – despite the absence of an Envelope-coding gene. We further identified an alternative fusogenic gene encoded in the genomes of these transposons, potentially substituting the Envelope’s role in enabling cell-cell transmission. By mining genomes, we found such fusogenic genes to be widespread in the context of transposons among insects, including clinically important mosquitoes. These findings, which introduce the concepts of infectious transposons or Envelope-less retroviruses, necessitate reconsideration and redefinition of the conventional boundaries between transposons and viruses.

Organized by Molecular Diversity of Microbes Team.
To meet the speaker and/or questions: alba.herrero-del-valle@pasteur.fr

Published on: 25 Sep 2023

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