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© Research
Event

« The dark side of DNA repair: trinucleotide repeat instability » by Vincent DION – Genomes & Genetics Departemental Seminar

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
20
Apr 2017
Time
11:00:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
Building: Jacques Monod
Location
2017-04-20 11:00:00 2017-04-20 00:30:00 Europe/Paris « The dark side of DNA repair: trinucleotide repeat instability » by Vincent DION – Genomes & Genetics Departemental Seminar Vincent DION Abstract: The normal DNA repair machinery is essential for maintaining genome stability, yet it has a dark side: it makes mistakes at repetitive sequences. The resulting rearrangements can be evolutionary beneficial or […] Institut Pasteur, Rue du Docteur Roux, Paris, France Guy-Franck Richard guy-franck.richard@pasteur.fr

About

Vincent DION

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Abstract:

The normal DNA repair machinery is essential for maintaining genome stability, yet it has a dark side: it makes mistakes at repetitive sequences. The resulting rearrangements can be evolutionary beneficial or cause pathologies. For instance, the expansion of CAG/CTG repeats causes at least 14 different neurological disorders that all remain without a cure. Since the longer the CAG/CTG tract, the more severe the symptoms are, it has been proposed that contracting the repeat tract to a normal length may provide a therapeutic avenue. Expansions, by contrast, would exacerbate the disease. Here I will talk about two different projects: 1) how the CRISPR-Cas9 nickase can be used to contract expanded repeat tract specifically. 2) How we can use a novel inducible chromatin targeting assay to dissect the local role of chromatin structure in expanded repeat instability and expression.

Location

Building: Jacques Monod
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France