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© Michel Huerre
Coupe histologique de foie de patient atteint d'une hépatite C chronique active avec infiltrat (opacité) folliculaire (lymphocytes) (Grossissement X 400). L'hépatite C chronique peut être à l'origine de cirrhose et cancer du foie
Scientific Fields
Diseases
Organisms
Applications
Technique
Date
22
May 2017
Time
14:00:00
25-28 Rue du Docteur Roux, Paris, France
Address
Building: Bâtiment François Jacob Room: Auditorium Centre François Jacob
Location
2017-05-22 14:00:00 2017-05-22 15:00:00 Europe/Paris Pr Frederick P. ROTH – VIROLOGY DEPARTMENT SEMINAR Pr Frederick P. ROTH Donnelly Centre, Molecular Genetics & Computer Science, University of Toronto Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto Title of the seminar : “Expeditions in Genotype-phenotype mapping” “We can routinely sequence […] 25-28 Rue du Docteur Roux, Paris, France Yves Jacob yves.jacob@pasteur.fr

About

Pr Frederick P. ROTH

Donnelly Centre, Molecular Genetics & Computer Science, University of Toronto

Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto

Title of the seminar : “Expeditions in Genotype-phenotype mapping”

“We can routinely sequence genomes, but now we urgently need tools to interpret individual genomes — multi-level maps that can predict phenotype from genotype. My talk will explore genotype-phenotype mapping at three levels: 1) Towards first-level maps that identify which variants impact gene function, I will describe a deep mutational scanning framework to assess impact of all possible missense variants over the full length of a target protein. Towards second-level maps, capturing the physical network of interacting biomolecules that mediate gene functions, I will describe the Barcode Fusion Genetics Yeast Two-Hybrid (BFG-Y2H) technology to map protein interactions under multiple environmental conditions.  Towards third-level maps that model genetic interactions, the unexpected effect of variant combinations, I will describe use of engineered strain populations to reveal higher-order genetic interactions amongst ABC transporters in yeast.”

Invited by : Yves Jacob  (yves.jacob@pasteur.fr)

Location

Building: Bâtiment François Jacob
Room: Auditorium Centre François Jacob
Address: 25-28 Rue du Docteur Roux, Paris, France