THE APOPTOTIC FACTOR APAF1 INSIDE CELLS DURING CELL DEATH - Research - Institut Pasteur

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DSCB Seminar: Dr. Aissam Ikmi, EMBL Heidelberg, Germany – “Design principles of cnidarian shapes”

Qbio minisymposium: Probing tissue mechanics

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

03

Feb 2026

Time

11:00:00

Institut Pasteur, Rue du Docteur Roux, Paris, France

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Building: Monod Building Room: Agnès Ullmann Auditorium

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2026-02-03 11:00:00 2026-02-03 12:00:00 Europe/Paris THE APOPTOTIC FACTOR APAF1 INSIDE CELLS DURING CELL DEATH WANDA KUKULSKI University of Bern, Institute of Biochemistry and Molecular Medicine External attendees wishing to participate in the seminar are required to contact the following email address dbsc@pasteur.fr in order to obtain access to the […] Institut Pasteur, Rue du Docteur Roux, Paris, France Anna Sartori-Rupp anna.sartori-rupp@pasteur.fr

About

WANDA KUKULSKI

University of Bern, Institute of Biochemistry and Molecular Medicine

External attendees wishing to participate in the seminar are required to contact the following email address dbsc@pasteur.fr in order to obtain access to the Institut Pasteur premises

ABSTRACT

The cell death program known as apoptosis is essential for organisms to remove surplus cells. This mechanism is important during development as well as for everyday tissue maintenance. Apoptosis also prevents uncontrolled proliferation of potentially cancerous cells. During the program, cytochrome c is released from mitochondria where it interacts with Apaf1 in the cytosol. This is known as the formation of the apoptosome complex, a key event in apoptosis.

This complex serves as a platform for the activation of caspases that execute the dismantling of the cell. We have found that the inside cells, the apoptosome is a pleomorphic, continuous meshwork structure that forms transiently during cell death. In this talk, I will present our work towards understanding regulation and assembly of the apoptosome in situ.

Location

Building: Monod Building
Room: Agnès Ullmann Auditorium
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France

Published on: 15 Jan 2026 • Modified on: 16 Jan 2026

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