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SEMINAR “The varied roles of Notch in building the body plan”

Introduction to data analysis

© Institut Pasteur/Marco Gualtieri & Pauline Spéder

Event

SEMINAR “Cancers with early developmental origins: learning from fly neural stem cells”

Department of: Developmental and Stem Cell Biology

Member: Pauline Speder

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

20

Jan 2017

Time

12:00:00

25 Rue du Docteur Roux, Paris, France

Address

Building: Monod (66)

Location

2017-01-20 12:00:00 2017-01-20 13:15:00 Europe/Paris SEMINAR “Cancers with early developmental origins: learning from fly neural stem cells” Department of Developmental and Stem Cell Biology 2017 Seminar Series Friday 20th January — at 12.00 pm — Amphi Monod (Bât.66) SEMINAR “Cancers with early developmental origins: learning from fly neural stem cells” Invited […] 25 Rue du Docteur Roux, Paris, France Pauline Speder pauline.speder@pasteur.fr

About

Department of Developmental and Stem Cell Biology

2017 Seminar Series

Friday 20th January — at 12.00 pm — Amphi Monod (Bât.66)

SEMINAR “Cancers with early developmental origins: learning from fly neural stem cells”

Invited Speaker ⇒ Cédric Maurange

From IBDM (Institut de Biologie du Développement de Marseille)
UMR 7288 – CNRS

Hosted by Pauline Spéder

Abstract : Cancers with early developmental origins such as pediatric cancers are still poorly understood. What is their cell of origin? Why do they progress so rapidly? What are the underlying gene networks and deregulated developmental programs? We are using Drosophila as an archaic model to understand this phenomenon, and more generally the basic principles of tumorigenesis. Recently, we have identified a genetic module that is normally only active in fly neural stem cells during early development, but can be coopted upon early genetic alteration to drive rapid tumor growth. I will discuss the underlying mechanisms and how our results reveal the important role of conserved RNA binding proteins in the regulation of neural stem cell self-renewal during development and tumorigenesis.

Location

Building: Monod (66)
Address: 25 Rue du Docteur Roux, Paris, France

Published on: 09 Jan 2017 • Modified on: 17 Jan 2017

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